PMID: 3759550Aug 1, 1986Paper

Tumor radiosensitization through reductions in hemoglobin affinity

International Journal of Radiation Oncology, Biology, Physics
D W Siemann, L M Macler

Abstract

Alterations in the oxygen (O2) distribution in a tumor due to changes in the quantity of O2 carried in the blood can affect the response of a tumor to radiation. For example, the blood hemoglobin (Hb) level has been shown to be an important prognostic and therapeutic factor in radiation therapy. Another factor affecting the delivery of O2 to tissues is the Hb affinity for O2. Changes in Hb affinity for O2 result in shifts of the Hb-O2 dissociation curve which increase or decrease tissue oxygenation. The aim of the present studies was to determine whether reductions in Hb affinity prior to irradiation could improve the resultant tumor response. KHT sarcomas were irradiated in female C3H/HeJ mice, possessing either normal or reduced Hb affinities for O2 at the time of treatment. Changes in Hb affinity for O2 were induced by keeping tumor-bearing mice in a 12% O2 environment for various periods of time. Erythrocyte 2,3-diphosphoglycerate (2,3 DPG) was measured as an indicator of Hb affinity for O2. After 36 hr of low O2 exposure, 2,3 DPG levels increased 20-30%. This change in 2,3 DPG reflected a proportional decrease in Hb affinity for O2. Following the exposure of 12% O2, the animals were removed from the low O2 chamber and thei...Continue Reading

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