Tumor recurrence in the remnant urothelium of females undergoing radical cystectomy for transitional cell carcinoma of the bladder: long-term results from a single center

The Journal of Urology
Thomas AkkadHannes Steiner

Abstract

We analyzed the risk factors and incidence of secondary TCC of the remnant urothelium in women following radical cystectomy for TCC of the bladder. A total of 85 women with a mean age of 64.5 years with clinically localized TCC of the bladder underwent radical cystectomy between 1992 and 2004. Orthotopic bladder substitution was performed in 46 females, while 39 underwent nonorthotopic urinary diversion. Of the entire cohort 22 (26%) patients underwent cystectomy for multifocal or recurrent TCC. Followup examinations were performed at 6-month intervals. Mean followup in the entire cohort was 49.8 months (median 42). Intraoperative frozen sections obtained from the urethra and distal ureters were negative for TCC and CIS in all patients. Four women (4.7%) had TCC in the remnant urothelium at a mean of 56 months postoperatively. These patients had undergone cystectomy for multifocal or recurrent TCC (4 of 22 or 18%). No secondary TCC was seen in the 63 patients with solitary invasive or nonrecurrent bladder cancer (p <0.05). Urethral recurrence was found in 2 patients (4.3%) 65 and 36 months after orthotopic neobladder surgery, respectively. In the orthotopic group 1 patient (2.1%) had an upper urinary tract tumor 76 months after...Continue Reading

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Citations

Aug 5, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Rajinikanth Ayyathurai, Mark S Soloway
Dec 4, 2010·The Kaohsiung Journal of Medical Sciences·Osman ErgünIbrahim Metin Ciriş
Aug 25, 2012·European Urology·Georgios GakisUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Nov 8, 2008·BJU International·Candace F GranbergMichael L Blute
Oct 9, 2016·The Urologic Clinics of North America·Kamran Zargar-ShoshtariMichael A Poch
Oct 11, 2016·European Urology·Georgios GakisWassim Kassouf
Nov 4, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Arnulf StenzlMarkus Kuczyk
Aug 22, 2012·Nature Reviews. Urology·Tomasz DrewaArun Sharma
Jan 11, 2013·Scandinavian Journal of Urology·Renate PichlerHannes Steiner
Jan 30, 2021·Actas urologicas españolas·A Rodríguez-SerranoL Martínez-Piñeiro
Jun 22, 2021·Actas Urologicas Españolas·A Rodríguez-SerranoL Martínez-Piñeiro
Jul 17, 2021·Urologic Oncology·Ekaterina LaukhtinaUNKNOWN European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

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