PMID: 8948349Oct 1, 1996Paper

Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy

International Journal of Radiation Oncology, Biology, Physics
A W BlackstockJ E Tepper

Abstract

The combination of 5-fluorouracil (5FU) and radiation results in improved tumor control in a variety of gastrointestinal cancers. We propose the enhancement is related to radiation potentiating the antitumor effects of 5FU. To better understand the mechanism of the 5FU-radiation interaction, 19F nuclear magnetic resonance (NMR) spectroscopy experiments were performed to observed the tumor clearance and metabolism of 5FU. Experiments were performed on 10 3-6-week-old female (Nu/Nu) athymic nude mice. Flank tumors measuring approximately 1.0 cm in diameter 3 weeks following a subcutaneous injection of 1 x 10(6) human colon adenocarcinoma (HT-29) cells were studied. In our first group, all animals received an intravenous bolus injection of 5FU (100 mg/kg) immediately before spectroscopic analysis. Animals in the second group were first treated with a single tumor radiation dose of 10 Gy just before the 5FU injection and subsequent spectroscopy. Spectroscopic analysis was performed with a 2.0-T NMR spectroscopy system. The tumor retention of 5FU was prolonged in animals receiving radiation before the drug infusion. The tumor clearance rate of the 5FU for nonirradiated animals was 0.0178 +/- 0.0082/min vs. 0.0055 +/- 0.0027/min for ...Continue Reading

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Citations

Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Marc BischofDetlev Latz
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·L D StegmanB D Ross
Jun 29, 2005·Critical Reviews in Oncology/hematology·Hanneke W M van LaarhovenArend Heerschap
Jun 17, 2006·Cancer Investigation·Aaron C Spalding, Theodore S Lawrence
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greg O CronBernard Gallez
Jan 16, 2018·Technology in Cancer Research & Treatment·Yu-Jen ChenChen-Hsi Hsieh

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