Tumor segmentation analysis at different post-contrast time points: A possible source of variability of quantitative DCE-MRI parameters in locally advanced breast cancer

European Journal of Radiology
Valeria RomeoMarco Salvatore

Abstract

to assess if tumor segmentation analysis performed at different post-contrast time points (TPs) on dynamic images could influence the extraction of dynamic contrast enhanced (DCE)-MRI parameters in locally advanced breast cancer (LABC), and potentially represent a source of variability. forty patients with forty-two LABC lesions were prospectively enrolled and underwent breast DCE-MRI examination at 3 T. On post-processed dynamic images, enhancing tumor lesions were manually segmented at four different TPs: at the first post-contrast dynamic image in which the lesion was appreciable (TP 1) and at 1, 5 and 10 min after contrast-agent administration (TPs 2, 3 and 4, respectively) and corresponding DCE-MRI parameters were extracted. Friedman's test followed by Bonferroni-adjusted Wilcoxon signed rank test for post-hoc analysis was used to compare DCE-MRI parameters. Intra- and inter-observer reliability of DCE-MRI parameters measurements was assessed using the Intraclass Correlation Coefficient (ICC) analysis. Ktrans, Kep and iAUC were significantly higher when extracted from ROIs placed at TP1 and progressively decreased from TP 2-4. The intra-observer reliability ranged from good to excellent (ICC's: 0.894 to 0.990). The inter-o...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Dec 6, 2000·Journal of Magnetic Resonance Imaging : JMRI·C K Kuhl, H H Schild
May 5, 2005·British Journal of Cancer·M O LeachUNKNOWN Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK
May 17, 2005·Artificial Intelligence in Medicine·Tim W NattkemperUNKNOWN UK MARIBS Breast Screening Study
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark A Rosen, Mitchell D Schnall
May 2, 2009·Magnetic Resonance Imaging Clinics of North America·Marianne MoonJeffrey Weinreb
Sep 8, 2009·Seminars in Radiation Oncology·Jennifer Specht, Julie R Gralow
Nov 24, 2011·AJR. American Journal of Roentgenology·Riham H El KhouliDavid A Bluemke
Mar 7, 2012·Journal of Magnetic Resonance Imaging : JMRI·Hye Ryoung KooWoo Kyung Moon
Aug 7, 2012·The Breast : Official Journal of the European Society of Mastology·M L MarinovichN Houssami
May 2, 2014·Journal of Magnetic Resonance Imaging : JMRI·Darryl McClymontStuart Crozier
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Sep 30, 2016·Journal of Applied Clinical Medical Physics·Jung Kyu RyuGeon-Ho Jahng
Oct 11, 2017·European Journal of Radiology·Rebecca A P DijkhoffMonique Maas
Sep 8, 2018·Turkish Journal of Emergency Medicine·Haldun Akoglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Magnetic Resonance Imaging : JMRI
Yu Sub SungJeong Kon Kim
Medical Image Analysis
Albert Gubern-MéridaBram Platel
Veterinary and Comparative Oncology
M Keara BossD E Thrall
© 2021 Meta ULC. All rights reserved