Abstract
A group of EMT6 tumor bearing male BALB/c mice which had been treated with alpha-difluoromethylornithine (DFMO, a specific, irreversible inhibitor of ornithine decarboxylase, the enzyme which catalyzes the biosynthesis of putrescine), 8 mg/mouse, ip, 20 and 5 hrs before the 14C-putrescine dose, and a group of control animals were administered 14C-putrescine (0.5 muCi, 0.1 mCi/mmol, iv) 60 min prior to sacrifice. Radioactivity uptake data was obtained for the tumor and 13 major normal organs. In the control animals the tumor exhibited one of the highest uptakes of radioactivity. For DFMO-pretreated mice the radioactivity distribution among most of the normal tissues was not very different from that obtained for the control animals. However, the uptake into the tumor was enhanced by a factor of approximately 4. So, high tumor-to-tissue ratios (3.8, lung to 38, brain) were attained as a result of DFMO treatment.
References
Jan 1, 1978·Cancer·N Breslow
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Russell, S H Snyder
Jul 2, 1982·Science·A E PeggI S Zagon
Citations
Jan 1, 1995·Journal of Neuro-oncology·E S RedgateM Deutsch
Jan 1, 1986·Journal of Neuro-oncology·S S GoldmanE S Flamm
Aug 5, 2011·Amino Acids·R PoulinD Soulet
Jan 1, 1988·The International Journal of Biochemistry·F DezeureN Seiler
Jan 1, 1990·The International Journal of Biochemistry·N Seiler, F Dezeure
Jul 1, 1985·Life Sciences·D F LarsonD H Russell
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·D R HwangM J Welch
May 1, 1995·The International Journal of Biochemistry & Cell Biology·A E PeggJ K Coward
Aug 1, 1996·The International Journal of Biochemistry & Cell Biology·N SeilerJ P Moulinoux
Jul 12, 2002·Bioorganic & Medicinal Chemistry·Bénédicte MartinJean-Guy Delcros
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·D R HwangD Kadmon
Jan 27, 1995·The Journal of Biological Chemistry·M LessardR Poulin
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·N SeilerF Gerhart
Mar 16, 2013·Molecular and Cellular Biochemistry·Gérard LescoatFrançois Gaboriau
Jun 13, 2003·Journal of Medicinal Chemistry·Chaojie WangOtto Phanstiel
Jan 1, 1989·Life Sciences·R F MinchinK F Ilett
Nov 14, 2003·Journal of Medicinal Chemistry·Chaojie WangOtto Phanstiel IV
Oct 19, 2001·Journal of Medicinal Chemistry·B MartinJ G Delcros
Nov 1, 2002·Journal of Medicinal Chemistry·Jean-Guy DelcrosPhilippe Uriac