Tumor Size, an Additional Risk Factor of Local Recurrence in Low-Risk Endometrial Cancer: A Large Multicentric Retrospective Study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Giulio SozziGiovanni Scambia

Abstract

The identification of patients with endometrial cancer (EC) at higher risk for relapse is critical to individualize and better tailor postoperative treatment. No evidence is available regarding the possible association between tumor size (TS) and the risk of local recurrence. The purpose of this study was to analyze the correlation between TS and risk/type of recurrence in EC patients, stratified according to the new European Society of Medical Oncology-European Society of Gynecological Oncology-European Society for Radiotherapy and Oncology classification. Data of patients with histologically proven EC who received primary surgical treatment between November 1999 and June 2015 were retrospectively retrieved from 5 institutions. Optimal TS cutoff was calculated using a receiver operating characteristic curve. Site of recurrence as a function of TS and groups of risk were analyzed. Local recurrence-free survival, recurrence-free survival, and overall survival were calculated using the Kaplan-Meier method. Data of 1166 patients were analyzed. Among them, 514 (44.1%) had low-risk EC, 174 (14.9%) had intermediate risk EC, 173 (14.8%) had high-intermediate risk EC, and 305 (26.2%) had high-risk EC. A total of 134 (11.5%) women had r...Continue Reading

References

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Citations

Apr 12, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisKevin Holcomb
Sep 2, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giulio SozziVito Chiantera
Nov 18, 2020·Journal of Magnetic Resonance Imaging : JMRI·Kristine E FasmerIngfrid H S Haldorsen
Oct 17, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Vito Andrea CapozziRoberto Berretta
May 23, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Vito Andrea CapozziRoberto Berretta

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