Tumor size improves the accuracy of TNM predictions in patients with renal cancer

European Urology
Pierre I KarakiewiczJean-Jacques Patard

Abstract

Current staging for renal cancer (RC) does not directly rely on tumor size. We examined the increment in accuracy related to inclusion of pathologically determined tumor size in prediction of nodal metastases (N+), distant metastases (M+), and cancer-specific survival (CSS). Partial or radical nephrectomy was performed in 2245 patients with clear cell histology. Pathologic stages were T1a in 566, T1b in 490, T2 in 303, T3 in 831, and T4 in 55 patients. Tumor size was 0.5-25 cm (mean, 6.8). Multivariate models relied on 1997 and 2002 TNM variables and addressed N+, M+ disease, and CCS. Their accuracy was compared according to either the presence or absence of tumor size. In all univariate and multivariate models, tumor size was a statistically significant predictor of all outcomes (p< or =0.001). In all multivariate models, tumor size added between 3.7% and 0.8% to predictive accuracy of either 1997 or 2002 TNM categories. Tumor size represents a highly significant, multivariate, and informative predictor of RC outcomes and may warrant inclusion in future TNM revisions.

References

Jul 4, 2001·The Journal of Urology·M W KattanP Russo
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanMurray F Brennan
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amnon ZismanArie S Belldegrun
Dec 24, 2003·Cancer·Mary K GospodarowiczLeslie H Sobin
Oct 12, 2004·European Urology·Vincenzo FicarraWalter Artibani
Nov 13, 2004·The Journal of Urology·Jean-Jacques PatardAllan J Pantuck
Jun 22, 2005·European Urology·Hans-Stefan HofmannRolf-Edgar Silber
Oct 7, 2005·Cancer·Vincenzo FicarraJean-Jacques Patard

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Citations

Mar 28, 2008·Current Urology Reports·Kamal Mattar, Michael A S Jewett
Dec 25, 2012·Annals of Surgical Oncology·Quoc-Dien TrinhPierre I Karakiewicz
Jun 30, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Y RouachA Mejean
Jan 31, 2012·Urologic Oncology·Turun SongQiang Wei
Mar 23, 2011·The Journal of Urology·Jared M WhitsonMaxwell V Meng
Nov 9, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·C Maurin
Mar 2, 2010·European Urology·Jean-Christophe BernhardJean-Jacques Patard
Sep 18, 2009·The Journal of Urology·Hwang Gyun JeonEunsik Lee
Aug 18, 2009·The Journal of Urology·Giovanni LughezzaniPierre I Karakiewicz
Jul 21, 2009·The Journal of Urology·Grégory VerhoestJean-Jacques Patard
Dec 5, 2008·European Urology·Vincent CloutierPierre I Karakiewicz
Sep 9, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L ZiniP Karakiewicz
Sep 2, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M CrépelJ-J Patard
May 3, 2008·Urologic Oncology·Vito ManciniFrancesco P Selvaggi
Dec 7, 2007·European Urology·Karim BensalahJean-Jacques Patard
Oct 13, 2007·Critical Reviews in Oncology/hematology·John S LamRobert A Figlin
Aug 3, 2007·European Urology·Hendrik Van Poppel, Steven Joniau
Mar 14, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pierre I KarakiewiczJean-Jacques Patard
Oct 17, 2009·European Journal of Cancer Care·V Yurut-CalogluO Inci
Oct 22, 2011·The Journal of Urology·S Brookman-MayUNKNOWN CORONA Project (Collaborative Research on Renal Neoplasms Association)
Jan 10, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D P ZubacS A Haukaas
Jul 2, 2010·Current Opinion in Urology·Maxine SunPierre I Karakiewicz
Jun 9, 2007·Expert Review of Anticancer Therapy·Alberto BredaJohn S Lam
Mar 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ibrahim KartalHamit Ersoy

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