Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.

Journal of Natural Medicines
Siti SusantiHirosuke Oku

Abstract

The effectiveness of cancer chemotherapy is often limited by the toxicity to other tissues in the body. Therefore, the identification of non-toxic chemotherapeutics from herbal medicines remains to be an attractive goal to advance cancer treatments. This study evaluated the cytotoxicity profiles of 364 herbal plant extracts, using various cancer and normal cell lines. The screening found occurrence of A549 (human lung adenocarcinoma) specific cytotoxicity in nine species of herbal plants, especially in the extract of Arctium lappa L. Moreover, purification of the selective cytotoxicity in the extract of Arctium lappa L. resulted in the identification of arctigenin as tumor specific agent that showed cytotoxicity to lung cancer (A549), liver cancer (HepG2) and stomach cancer (KATO III) cells, while no cytotoxicity to several normal cell lines. Arctigenin specifically inhibited the proliferation of cancer cells, which might consequently lead to the induction of apoptosis. In conclusion, this study found that arctigenin was one of cancer specific phytochemicals, and in part responsible for the tumor selective cytotoxicity of the herbal medicine.

References

Nov 18, 1994·Cell·C J Sherr
Apr 1, 1994·Experimental Cell Research·R BertrandY Pommier
Nov 1, 1996·Biological & Pharmaceutical Bulletin·S MoritaniK Miyamoto
Jan 1, 1997·Journal of Natural Products·G M CraggK M Snader
Nov 20, 1998·JAMA : the Journal of the American Medical Association·D M EisenbergR C Kessler
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·T TanakaH Ogawa
Mar 17, 2001·Environmental Health Perspectives·D S Fabricant, N R Farnsworth
Aug 5, 2003·Journal of Cancer Research and Clinical Oncology·B HausottB Marian
May 13, 2004·Journal of Ethnopharmacology·R Ajaya KumarS Rajagopal
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R BuchananLori M Minasian
Nov 29, 2005·Molecular and Cellular Biochemistry·Rama S RangaDamodaran Chendil
Sep 28, 2006·JAMA : the Journal of the American Medical Association·Jules Hirsch
Nov 18, 2006·Journal of Zhejiang University. Science. B·Wen-jing RuanJian-guang Zhou
Mar 1, 2008·The Lancet Oncology·Heikki Joensuu
Nov 15, 2008·Nutrition and Cancer·Takuji TanakaTakeru Oyama
Mar 17, 2010·Journal of Cellular Physiology·Ju-Young KimHae-Ryong Park
Jun 1, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ji-Hye YooChu Won Nho

❮ Previous
Next ❯

Citations

Jan 23, 2015·Pharmaceutical Biology·Hongbin LiuShuo Chen
Sep 12, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Siti SusantiHirosuke Oku
Jul 8, 2016·Chemical & Pharmaceutical Bulletin·En-Bo CaiMan-Ling Zheng
Dec 4, 2015·Iranian Journal of Cancer Prevention·Maryam EsmaeilbeigZahra Amirghofran
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mingdi ZhangZhiwei Quan
Jul 5, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Masahiko SuzukiHisashi Kato-Noguchi
Jun 4, 2014·Anti-cancer Drugs·Yuezhou ChenWenpeng Zhang
Apr 8, 2020·Journal of Functional Biomaterials·Kimin KimJu Hun Yeon
Nov 19, 2020·Natural Product Research·Judith Flore T MbougniaNorbert Sewald
Jul 26, 2021·Molecular Biology Reports·Km Anjaly, A B Tiku
Oct 7, 2021·The Journal of Pharmacy and Pharmacology·Ying LiChang-Zheng Zhou
Mar 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xixi ChengYurong Da
May 3, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Feng HanPu-Xun Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.