PMID: 11932911Apr 5, 2002Paper

Tumor specific gene expression profiles in human leiomyosarcoma: an evaluation of intratumor heterogeneity

Cancer
Ilya ShmulevichWei Zhang

Abstract

Leiomyosarcomas are malignant smooth muscle tumors characterized by a spectrum of histopathologic features and clinical behavior. Gene expression profiling of leiomyosarcomas may identify differential gene signatures that may allow for the clinical stratification of the tumors. Typically, surgical specimens from these tumors are large and manifest a variegated macroscopic appearance. Because of their large size at the time of diagnosis, sufficient tissue is available for regional and clonal heterogeneity assessment. However, if the gene expression profiles of samples taken from different locations in the tumors are drastically different, biologic classification on the basis of random sample analysis may not be adequate. Therefore, to assess intertumor and intratumor heterogeneity, the authors performed a gene expression study using leiomyosarcoma specimens from three excised sarcomas from an equal number of different patients. Comparisons between tumor and normal samples from the three patients as well as between carefully mapped peripheral and core specimens from the same tumor (excised from one of the patients), were performed. Analysis of the expression profiles demonstrated minimal intratumor variations compared with intert...Continue Reading

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Citations

May 27, 2004·Current Oncology Reports·Keith M Skubitz, Amy P N Skubitz
Mar 26, 2003·Nucleic Acids Research·Ilya ShmulevichWei Zhang
Mar 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K M JochumsenO Mogensen
Mar 16, 2005·BMC Bioinformatics·Harri LähdesmäkiWei Zhang
Sep 20, 2005·Genome Biology·Stephen R HendersonChris Boshoff
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nathan D PriceWei Zhang
Feb 10, 2007·Expert Review of Anticancer Therapy·Joseph G Sinkovics
Jun 9, 2007·Critical Reviews in Oncology/hematology·Katharina TschoepRolf-Dieter Issels
Apr 19, 2005·Genes, Chromosomes & Cancer·Princy FrancisMef Nilbert
Aug 28, 2003·Cancer·Keith M Skubitz, Amy P N Skubitz
Jun 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Josefin FernebroMef Nilbert
Dec 12, 2012·The American Journal of Pathology·Wusheng YanHeidi S Erickson
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Torsten O Nielsen, Robert B West
Mar 23, 2006·Technology in Cancer Research & Treatment·Matti NykterWei Zhang
Nov 13, 2003·Clinical Orthopaedics and Related Research·R Lor RandallDavid Joyner
Sep 1, 2005·Clinical Orthopaedics and Related Research·R Lor RandallDavid E Joyner
Jun 3, 2017·Scientific Reports·Kyle M SchachtschneiderLawrence B Schook
Jan 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antoine ItalianoFrédéric Chibon
Jun 27, 2003·Human Pathology·Baoguo RenUma N M Rao

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