Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma

International Journal of Cancer. Journal International Du Cancer
Beyhan CengizHitoshi Nagatsuka

Abstract

Our previous study showed high frequency of allelic loss at chromosome 2q37 region in oral cancer. This location contains several candidate tumor suppressor genes such as PPP1R7, ILKAP, DTYMK and ING5. We previously showed 3 members of inhibitor of growth (ING) family, ING1, ING3 and ING4 as tumor suppressor gene in head and neck cancer. As ING5 shows high homology with other members of ING genes including highly conserved carboxy-terminal plant homeodomain and nuclear localization signal, we first picked up ING5 and examined it as a possible tumor suppressor in oral cancer. For this aim, mutation and mRNA expression status of ING5 in paired normal and oral squamous cell carcinoma samples were examined by reverse transcription polymerase chain reaction (RT-PCR) and sequencing. Three missense mutations located within leucine zipper like (LZL) finger and novel conserved region (NCR) domains in ING5 protein were detected, probably abrogating its normal function. We also found 5 different alternative splicing variants of ING5. Then, we examined mRNA level of ING5 by quantitative real time reverse transcription polymerase chain reaction (qRT-PCR) analysis, which demonstrated decreased expression of ING5 mRNA in 61% of the primary tu...Continue Reading

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A HaberD E Housman
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Feb 1, 1994·Current Opinion in Genetics & Development·P W Hinds, R A Weinberg
Dec 2, 1993·International Journal of Cancer. Journal International Du Cancer·P PisaniJ Ferlay
Jan 31, 2003·Molecular and Cellular Biology·Feng BaiYue Xiong
May 4, 2004·Nature Biotechnology·Mariano A Garcia-BlancoErika L Lasda
Dec 9, 2004·International Journal of Oncology·Esra GunduzNoriyuki Nagai
Apr 10, 2007·The International Journal of Biochemistry & Cell Biology·Rolf I Skotheim, Matthias Nees
Oct 24, 2007·Trends in Biochemical Sciences·Mohamed A Soliman, Karl Riabowol
Jun 10, 2008·Current Cancer Drug Targets·Mehmet GunduzHitoshi Nagatsuka

❮ Previous
Next ❯

Citations

Nov 19, 2011·Cancer Metastasis Reviews·Seyed Mehdi Jafarnejad, Gang Li
Nov 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin Qi, Yang Zhang
Aug 31, 2010·Cellular and Molecular Life Sciences : CMLS·Almass-Houd Aguissa-TouréGang Li
Dec 3, 2014·Molecular Oncology·Fernanda Bernardi BertonhaSilvia Regina Rogatto
Dec 18, 2013·Cancer Letters·Claire GuérillonRémy Pedeux
Oct 31, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Brianna J KleinTatiana G Kutateladze
Aug 22, 2016·Journal of Cancer Research and Clinical Oncology·Runyun ZhangYongzhong Hou
Jan 15, 2017·Journal of Ovarian Research·Wen-Ting ChenBing Yang
Jan 18, 2018·Cancer Investigation·Habib ZarredarSafar Farajnia
Sep 3, 2019·Cell Biology International·Neslisah BarlakOmer Faruk Karatas
May 12, 2017·Molecular Cancer·Shufang CuiXi Chen
Apr 30, 2017·Oncology Letters·Wen-Feng GouHua-Chuan Zheng
Jan 19, 2019·Oncology Letters·Xue-Feng YangHua-Chuan Zheng
Apr 12, 2013·Cancer Research·Nansong LiuHong Lu
Jan 24, 2019·Cancer Letters·Marjorie GournayRémy Pedeux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.