Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors

Japanese Journal of Cancer Research : Gann
Y YamaguchiS Muramatsu

Abstract

T cells prepared from tumor (Meth A)-bearing mice were cocultured with homologous tumor cells and splenic dendritic cells to enrich tumor-specific T cells by the separation of clusters. T blasts generated from clusters were capable of inhibiting the in vivo tumor cell growth. The culture supernatant of clustering cells (CLSN) was effective in activating macrophages (M phi) to be cytostatic and cytocidal against tumor cells. Moreover, it was found that CLSN contains at least 3 distinct factors; one was identified as interferon-gamma (IFN-gamma), and the others are so far unidentified, but one acts synergistically with IFN-gamma, possibly as the second signal, and the other cooperates with lipopolysaccharide but not with IFN-gamma. We propose that the tumor-specific T cells secrete soluble mediators which cooperate with each other in M phi activation against tumor cells.

References

Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K InabaR M Steinman
Jan 1, 1984·Annual Review of Immunology·D O Adams, T A Hamilton
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May 1, 1980·The Journal of Experimental Medicine·M C Nussenzweig, R M Steinman

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Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·K UnoS Muramatsu
May 1, 1991·Japanese Journal of Cancer Research : Gann·M TakemaS Muramatsu
Jul 26, 2005·Journal of Comparative Pathology·W S SpragueE A Hoover

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