Tumor spread through air spaces is a useful predictor of recurrence and prognosis in stage I lung squamous cell carcinoma, but not in stage II and III

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Naoki YanagawaShin-Ya Ogata

Abstract

Tumor spread through air spaces (STAS) is a newly identified invasion pattern in lung adenocarcinoma. This study aimed to analyze and validate the clinical impact of tumor STAS in surgically resected lung squamous cell carcinoma (SQCC). We retrospectively reviewed 220 patients with lung SQCC. Tumor STAS was defined as detached tumor cells within the air spaces in the lung parenchyma beyond the edge of the main tumor. Statistical analyses were conducted to investigate the proportion of STAS and the relationship between the presence of STAS and clinicopathological factors, including clinical outcome. STAS was identified in 42 of 220 patients (19.1%). The patients with STAS had a significantly worse 5-year recurrence-free survival (RFS) and 5-year overall survival (OS) than those without STAS (5-year RFS: 37.4% vs. 68.4%; p = 0.0006; 5-year OS: 50.2% vs. 71.4%, p = 0.0078) in stage I, but not in stage II and III. A multivariate analysis showed that the presence of STAS was an independent predictive factor of recurrence (hazard ratio = 3.27; 95% confidence interval, 1.7-6.29; p = 0.0004) and an independent prognostic factor (hazard ratio = 3.01; 95% confidence interval, 1.54-5.89; p = 0.0013) in stage I, but not in stage II and III...Continue Reading

Citations

Dec 5, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christina NepplSabina Berezowska
Jan 17, 2020·Histopathology·Angela R Shih, Mari Mino-Kenudson
May 20, 2020·Cancer Management and Research·Meng JiaPing-Li Sun
Nov 18, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yeon Bi HanJin-Haeng Chung
May 24, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rania G AlyWilliam D Travis
May 6, 2021·Thoracic Cancer·Toshihiro IkedaHiroyasu Yokomise

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