Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.

Cancer Metastasis Reviews
Fidel Nicolás LoloMiguel Ángel Del Pozo

Abstract

Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.

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Citations

Dec 4, 2020·International Journal of Nanomedicine·Xiaowei WangRongguang Shao
Aug 28, 2021·International Journal of Molecular Sciences·Daniela LisiniGiulia Maria Stella

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Methods Mentioned

BETA
glycosylation
GTPase
super-resolution microscopy
electron microscopy
xenografting

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