Abstract
Tumor tissue is composed of both cancer cells and stromal cells recruited from normal tissue. These cells include fibroblastic cells, endothelial cells, and cells of hematopoietic origin. The host-derived stromal cells play a critical role in all aspects of cancer biology including transformation, progression, tumor growth, and drug resistance. The interactions between stromal cells and cancer cells are of intense interest, and their complex interactions are beginning to be identified. Therapies that target components of the tumor microenvironment are showing efficacy in the clinic, particularly when used in combination with other therapeutic agents. In general these agents have been well tolerated, and targeting the stromal components may be a strategy for circumventing the problem of drug resistance. In this review, we highlight major stromal components, their interactions with tumor cells, and therapeutic approaches that disrupt host-tumor cell interactions. Advances in understanding host stromal components with respect to origin, subsets, and their signaling networks will reveal novel targets. Synergistic approaches that disrupt multiple host-tumor cell signaling pathways will lead to more effective therapies for cancer.
Citations
Apr 12, 2011·Breast Cancer Research and Treatment·Patricia A GanzSteven W Cole
Mar 5, 2011·International Journal of Hematology·Tomonori YaguchiYutaka Kawakami
Nov 3, 2012·British Medical Bulletin·Helmout ModjtahediSharadah Essapen
Apr 12, 2013·Journal of Translational Medicine·Jennifer PasquierArash Rafii
Dec 8, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Humberto Treviño-VillarrealRick A Rogers
Apr 18, 2012·PloS One·Daniela De StefanoRosa Carnuccio
May 23, 2014·PloS One·Wen XuWensheng Pan
Oct 12, 2014·Journal of Translational Medicine·Cyril TouboulArash Rafii
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kai WangYufeng Cheng
Nov 6, 2012·Trends in Molecular Medicine·Robert G EvansMichael Khan
Sep 25, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Magdalena BodnarAndrzej Marszalek
Apr 5, 2013·Investigational New Drugs·Yu SunakawaYasutsuna Sasaki
Jun 1, 2013·Cell Adhesion & Migration·Muthulekha SwamydasDidier Dréau
Jul 16, 2011·Leukemia Research·Mariko IshibashiKiyoyuki Ogata
Mar 27, 2015·PloS One·Emma PiriläTuula Salo
Nov 27, 2015·BioMed Research International·Ying ChenXiangyu Liu
Jan 20, 2017·Cell Death & Disease·Jeremy Soon Kiat ChanNguan Soon Tan
May 24, 2018·Drug Delivery·Xiang LuoYanzhi Song
Jan 26, 2018·Oncogene·Eddie Han Pin TanNguan Soon Tan
Feb 10, 2019·Cancers·Andrés M CastellaroGermán A Gil
Oct 9, 2019·Nutrients·Antonio Giordano, Giuseppina Tommonaro
Nov 21, 2019·Small·Zhengjie LinZhou Liu
Jul 1, 2011·Experimental and Therapeutic Medicine·Shigeki FujitaKatsuyuki Aozasa
Apr 1, 2019·Molecular Cancer·Yidi QuDi Wang
Feb 22, 2012·Cancer Research·Miao GuoShereen Ezzat
Feb 22, 2014·Cancer Research·Wenxia MengHongmei Zhou
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sabira SultanaKannan R R Rengasamy
Jun 26, 2021·Carcinogenesis·Yu ZhengChangqing Zeng
Aug 20, 2021·AAPS PharmSciTech·Jing SunYanzhi Song