Tumor-stromal cell interactions and opportunities for therapeutic intervention

Current Opinion in Pharmacology
Taturo Udagawa, Mark Wood

Abstract

Tumor tissue is composed of both cancer cells and stromal cells recruited from normal tissue. These cells include fibroblastic cells, endothelial cells, and cells of hematopoietic origin. The host-derived stromal cells play a critical role in all aspects of cancer biology including transformation, progression, tumor growth, and drug resistance. The interactions between stromal cells and cancer cells are of intense interest, and their complex interactions are beginning to be identified. Therapies that target components of the tumor microenvironment are showing efficacy in the clinic, particularly when used in combination with other therapeutic agents. In general these agents have been well tolerated, and targeting the stromal components may be a strategy for circumventing the problem of drug resistance. In this review, we highlight major stromal components, their interactions with tumor cells, and therapeutic approaches that disrupt host-tumor cell interactions. Advances in understanding host stromal components with respect to origin, subsets, and their signaling networks will reveal novel targets. Synergistic approaches that disrupt multiple host-tumor cell signaling pathways will lead to more effective therapies for cancer.

Citations

Mar 5, 2011·International Journal of Hematology·Tomonori YaguchiYutaka Kawakami
Nov 3, 2012·British Medical Bulletin·Helmout ModjtahediSharadah Essapen
Dec 8, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Humberto Treviño-VillarrealRick A Rogers
Oct 12, 2014·Journal of Translational Medicine·Cyril TouboulArash Rafii
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kai WangYufeng Cheng
Nov 6, 2012·Trends in Molecular Medicine·Robert G EvansMichael Khan
Sep 25, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Magdalena BodnarAndrzej Marszalek
Nov 27, 2015·BioMed Research International·Ying ChenXiangyu Liu
Jan 20, 2017·Cell Death & Disease·Jeremy Soon Kiat ChanNguan Soon Tan
Oct 9, 2019·Nutrients·Antonio Giordano, Giuseppina Tommonaro
Jul 1, 2011·Experimental and Therapeutic Medicine·Shigeki FujitaKatsuyuki Aozasa
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sabira SultanaKannan R R Rengasamy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.