Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.

FEBS Letters
Ursula E LeeScott L Friedman

Abstract

The tumor suppressor Kruppel-like factor 6 (KLF6) is frequently inactivated in hepatocellular carcinoma (HCC). To unearth downstream transcriptional targets of KLF6, cDNA microarray analysis of whole liver was compared between KLF6+/+ and KLF6+/- mice. Pituitary tumor transforming gene 1 (PTTG1), an oncogene, was the most up-regulated transcript in KLF6+/- liver. In human HCCs, KLF6 mRNA was significantly decreased, associated with increased PTTG1. In HepG2, KLF6 transcriptionally repressed PTTG1 by direct promoter interaction. Whereas KLF6 downregulation by siRNA increased HepG2 proliferation, siRNA to PTTG1 was anti-proliferative. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6.

References

Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·V RatziuS L Friedman
Oct 31, 2002·The Journal of Biological Chemistry·Yunli ZhouXun Zhang
Mar 31, 2004·Cancer Cell·Jordi BruixJosep M Llovet
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sigal Kremer-TalScott L Friedman
Oct 20, 2005·Blood·Nobuyuki MatsumotoScott L Friedman
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tsutomu FujiiAkimasa Nakao
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jung Cho-RokDong-Soo Im
Jul 6, 2006·International Journal of Oncology·Sham S Kakar, Mohammad T Malik
Feb 28, 2007·Endocrine Reviews·George VlotidesShlomo Melmed
Jul 4, 2008·The Journal of Clinical Investigation·Goutham NarlaJohn A Martignetti

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Citations

Aug 9, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S Q HuangG Ye
Feb 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Jie LuShijie Ma
Aug 12, 2016·International Journal of Immunopathology and Pharmacology·Pei-Hao WenWen-Zhi Guo
Sep 26, 2013·Nature Reviews. Cancer·Marie-Pier TetreaultJonathan P Katz
Aug 16, 2017·Scientific Reports·Svenja SydorLars P Bechmann
May 29, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Svenja SydorLars P Bechmann
Apr 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaopei ZhaoHua Tang

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