Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells.

International Journal of Cancer. Journal International Du Cancer
Kateřina KratochvílováPetr Vaňhara

Abstract

Ovarian cancer is one of the most common malignancies in women and contributes greatly to cancer-related deaths. Tumor suppressor candidate 3 (TUSC3) is a putative tumor suppressor gene located at chromosomal region 8p22, which is often lost in epithelial cancers. Epigenetic silencing of TUSC3 has been associated with poor prognosis, and hypermethylation of its promoter provides an independent biomarker of overall and disease-free survival in ovarian cancer patients. TUSC3 is localized to the endoplasmic reticulum in an oligosaccharyl tranferase complex responsible for the N-glycosylation of proteins. However, the precise molecular role of TUSC3 in ovarian cancer remains unclear. In this study, we establish TUSC3 as a novel ovarian cancer tumor suppressor using a xenograft mouse model and demonstrate that loss of TUSC3 alters the molecular response to endoplasmic reticulum stress and induces hallmarks of the epithelial-to-mesenchymal transition in ovarian cancer cells. In summary, we have confirmed the tumor-suppressive function of TUSC3 and identified the possible mechanism driving TUSC3-deficient ovarian cancer cells toward a malignant phenotype.

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Citations

Feb 26, 2016·European Journal of Cell Biology·Kateřina KratochvílováPetr Vaňhara
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenfeng JiangZhiguo Lin
Feb 6, 2017·Endocrine-related Cancer·Jennifer Munkley
Mar 9, 2017·Journal of Cellular and Molecular Medicine·Xinshuang YuJuan Du
Apr 12, 2019·Diagnostics·Varun Chandra AlurChanabasayya Vastrad
Dec 21, 2017·Cancers·Trung Vu, Pran K Datta
Dec 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ya-Guang LiShan-Qing Li
Jul 28, 2019·Metallomics : Integrated Biometal Science·Lukáš MoráňPetr Vaňhara
Dec 8, 2019·International Journal of Molecular Sciences·Yoichiro HaradaNaoyuki Taniguchi
Sep 21, 2017·Cellular and Molecular Life Sciences : CMLS·Kateřina VašíčkováPetr Vaňhara
Aug 28, 2020·Frontiers in Pharmacology·Jun LiYingyan Yu
Nov 21, 2021·Cancer Immunology, Immunotherapy : CII·Trefa M AbdullahPaul Eggleton

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