Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling

Journal of Proteome Research
Yang LiuJian-Ting Zhang

Abstract

Lung cancer, a leading cause of cancer deaths, consists of two major groups: small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC) with the NSCLC accounting for approximately 75% cases of lung cancers. It has been suggested that molecular changes including overexpression of oncogenes and decreased expression of tumor suppressor genes are responsible for lung carcinogenesis. In this study, we analyzed protein profiles of four different human NSCLC cell lines compared with normal human bronchial epithelial cells using two-dimensional PAGE and MALDI-TOF mass spectrometry. We identified 12 protein spots with different expressions between the normal and cancer cells. Of these proteins, vimentin, cytokeratin 8, YB-1, PCNA, Nm23, hnRNP A2/B1, and HSP90beta were known to be up-regulated in lung cancers, which is consistent with the current study. We also found that the expression of M-type pyruvate kinase is altered in NSCLC likely due to changes in translational control and/or differential phosphorylation of the protein. Interestingly, the expression of the tumor suppressor gene 14-3-3sigma is down-regulated while that of the proto-oncogene TEF1delta is up-regulated in NSCLC cells. On the basis of these observations and ...Continue Reading

Citations

May 13, 2005·Nucleic Acids Research·Zizheng DongJian-Ting Zhang
Feb 1, 2008·Proteomics. Clinical Applications·Franck BrouillardMario Ollero
Sep 15, 2006·Proteomics·Yasuhiro Kuramitsu, Kazuyuki Nakamura
Aug 15, 2009·Journal of Cellular Physiology·Andy T Y Lau, Jen-Fu Chiu
Apr 21, 2006·Biochimica Et Biophysica Acta·Frédéric Le SourdOdile Mulner-Lorillon
Dec 23, 2011·Journal of Proteome Research·Youyun YangJian-Ting Zhang
Apr 16, 2009·British Journal of Cancer·K HellmanG Auer
Jan 30, 2016·Clinical Science·Isadora L FloresAdriana F Paes Leme
Sep 1, 2018·In Vitro Cellular & Developmental Biology. Animal·Payal AgarwalR Curtis Bird
Jun 3, 2011·Molecular and Cellular Biochemistry·Huiling WuKeke Huo
May 2, 2006·Molecular Cancer Therapeutics·Baoguang HanJian-Ting Zhang
Jan 15, 2017·Molecular Cancer Research : MCR·Yifan ChenJian-Ting Zhang
Aug 20, 2019·Trends in Molecular Medicine·Chunyang JiangZhigang Zhao

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