Abstract
Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.
References
Dec 11, 2002·Journal of Cancer Research and Clinical Oncology·Jian MaGui-Yuan Li
Aug 15, 2003·World Journal of Gastroenterology : WJG·Xiao-Mei ZhangJiang Li
Feb 6, 2004·Gene Therapy·I A McNeishN R Lemoine
Oct 23, 2004·Carcinogenesis·Jian MaGuiyuan Li
Feb 22, 2005·Journal of Cellular Biochemistry·Lili WangGuiyuan Li
Sep 22, 2006·Clinical Medicine & Research·Deanna Cross, James K Burmester
Feb 3, 2007·Cancer Science·Shuping PengGuiyuan Li
Jul 21, 2007·Oncology·Shu-Ping PengGui-Yuan Li
Apr 9, 2009·Molecular and Cellular Biochemistry·Qin GuoShourong Shen
Jun 6, 2009·Acta Biochimica Et Biophysica Sinica·Ya PengShourong Shen
Sep 17, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Li WangGui-Yuan Li
Dec 2, 2009·Current Genomics·Minghua WuGuiyuan Li
Apr 29, 2010·BMC Cancer·Minji LiuGuiyuan Li
Aug 14, 2010·Acta Biochimica Et Biophysica Sinica·Qin GuoXiaoyan Wang
Sep 23, 2010·Molecular and Cellular Biochemistry·Xiao-Yan WangShou-Rong Shen
Oct 23, 2010·BMC Cancer·Michelle M S ChewEng-Lai Tan
Jan 1, 2010·Molecular Medicine Reports·Lei ZhouJingang Liu
Sep 16, 2011·Nature Reviews. Cancer·Ya CaoKaren Vousden
Jun 1, 2012·Acta Biochimica Et Biophysica Sinica·Yu LiZheng Su
Oct 12, 2012·Molecular Biology Reports·Ebrahim Eskandari-NasabMohsen Taheri
Apr 17, 2013·International Journal of Oncology·Wen-Jing Zhao, Ke Wang
Dec 18, 2013·Medical Oncology·Jian LiuDongqiu Dai
Jul 18, 2014·BMC Molecular Biology·Minji LiuGuiyuan Li
Nov 8, 2014·The Journal of Biological Chemistry·Li WangGuiyuan Li
Apr 9, 2015·World Journal of Gastroenterology : WJG·Adriana M Salazar-MontesJuan Armendariz-Borunda