Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Shiwei HeShuping Peng

Abstract

Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.

References

Dec 11, 2002·Journal of Cancer Research and Clinical Oncology·Jian MaGui-Yuan Li
Aug 15, 2003·World Journal of Gastroenterology : WJG·Xiao-Mei ZhangJiang Li
Sep 22, 2006·Clinical Medicine & Research·Deanna Cross, James K Burmester
Jun 6, 2009·Acta Biochimica Et Biophysica Sinica·Ya PengShourong Shen
Sep 17, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Li WangGui-Yuan Li
Sep 23, 2010·Molecular and Cellular Biochemistry·Xiao-Yan WangShou-Rong Shen
Sep 16, 2011·Nature Reviews. Cancer·Ya CaoKaren Vousden
Apr 9, 2015·World Journal of Gastroenterology : WJG·Adriana M Salazar-MontesJuan Armendariz-Borunda

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Citations

Mar 8, 2019·The Journal of Clinical Investigation·Eléna GonçalvesBehazine Combadière
Dec 8, 2020·Journal of Biomaterials Applications·Reza MahmoudiHassan Bardania

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