Abstract
To identify predictive factors of tumor response, progression-free survival (PFS), overall survival (OS), and toxicity using three-dimensional (3D) voxel-based dosimetry in patients with intermediate and advanced stage hepatocellular carcinoma (HCC) treated by yttrium-90 (90Y) resin microspheres radioembolization (RE). From February 2012 to December 2015, 45 90Y resin microspheres RE procedures were performed for HCC (Barcelona Clinic Liver Cancer stage B/C; n = 15/30). Area under the dose-volume histograms (AUDVHs) were calculated from 3D voxel-based dosimetry to measure 90Y dose deposition. Factors associated with tumor control (ie, complete/partial response or stable disease on Modified Response Evaluation Criteria in Solid Tumors) at 6 months were investigated. PFS and OS analyses were performed (Kaplan-Meier). Toxicity was assessed by occurrence of radioembolization-induced liver disease (REILD). Tumor control rate was 40.5% (17/42). Complete tumor targeting (odds ratio = 36.97; 95% confidence interval, 1.83-747; P < .001) and AUDVHtumor (odds ratio = 1.027; 95% confidence interval, 1.002-1.071; P = .033) independently predicted tumor control. AUDVHtumor ≥ 61 Gy predicted tumor control with 76.5% sensitivity and 75% specif...Continue Reading
Citations
Jan 10, 2019·Journal of Clinical Medicine·Aman SainiRahmi Oklu
Oct 5, 2019·Medical Physics·Carlo ChiesaHabib Zaidi
Jun 18, 2020·Cancers·Etienne GarinYan Rolland
Apr 14, 2020·Digestive Diseases and Sciences·Carlos Moctezuma-VelazquezRichard J Owen
Jul 2, 2020·Radiology·Constantinos T Sofocleous, Nikiforos Vasiniotis Kamarinos
Feb 7, 2021·Scientific Reports·Mai Hong SonJin Chul Paeng
Feb 20, 2021·Abdominal Radiology·I KurilovaC T Sofocleous
Mar 4, 2021·Cancer Biotherapy & Radiopharmaceuticals·Dimitris PlachourisGeorge C Kagadis
Mar 5, 2021·EJNMMI Research·Macarena Rodríguez-FraileJosé Ignacio Bilbao
Apr 12, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Joey RoosenJ Frank W Nijsen
Nov 29, 2020·Seminars in Radiation Oncology·Stephen A Graves, Robert F Hobbs
Nov 2, 2019·La Presse médicale·Lauranne PironBoris Guiu
Oct 6, 2020·Diagnostic and Interventional Imaging·M GhosnV Tacher
May 28, 2021·World Journal of Gastrointestinal Oncology·Mohammad ElsayedNima Kokabi
Jun 3, 2021·Diagnostics·Carole AllimantBoris Guiu
Apr 3, 2021·Nuclear Medicine Communications·Bernard ChengNima Kokabi
Jul 10, 2021·Journal of Vascular and Interventional Radiology : JVIR·Sandi A KweeDouglas P Landsittel
Aug 29, 2021·Journal of Vascular and Interventional Radiology : JVIR·Ammar SarwarMuneeb Ahmed
Oct 11, 2021·Medical Physics·Dimitris PlachourisGeorge C Kagadis
Oct 23, 2021·Frontiers in Oncology·Michel HesseStephan Walrand
Aug 16, 2021·Nuclear Medicine Communications·Min Young YooGi Jeong Cheon