Tumor-Targeting Anti-MicroRNA-155 Delivery Based on Biodegradable Poly(ester amine) and Hyaluronic Acid Shielding for Lung Cancer Therapy

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Yi YangZhi Yong Qian

Abstract

Anti-microRNA-155 (anti-miR-155), an oligonucleotide with a complimentary sequence to microRNA-155, holds great promise for lung cancer therapy, and thus some cationic materials have been used to deliver anti-miR-155 into lung tumors. Although the gene delivery capacity in vitro was favorable, the application in vivo was limited by rapid removal and significant cytotoxicity, which were mainly caused by the positive charge of the gene complexes. Therefore, it was necessary to develop a novel carrier to decrease the positive charge and increase the gene delivery capacity into the tumor site. In this paper, biodegradable poly(ester amine) (PEA) was used to condense anti-miR-155 into PEA/anti-miR-155 complexes, and natural anionic polysaccharide hyaluronic acid (HA) was modified with a lung tumor cell targeting peptide and then coated on the surface of gene complexes. The formed hyaluronic acid shielding, PEA/anti-miR-155/HA-peptide complexes were monodispersed, and the particle size and zeta potential were 362.7 nm and -10.17 mV, respectively. In addition, the PEA/anti-miR-155/HA-peptide complexes had good biocompatibility and stability in vitro, and the lung tumor growth inhibitions of PEA/anti-miR-155/HA-peptide in vitro and in ...Continue Reading

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May 11, 2019·Expert Opinion on Drug Delivery·Dmitri A Ossipov
Sep 24, 2019·Current Pharmaceutical Biotechnology·Konrad DziobekDariusz Boroń
Mar 20, 2020·Expert Review of Molecular Diagnostics·Yin Lam ChuSze Chuen Cesar Wong
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Sep 29, 2019·Molecular Aspects of Medicine·Diana GuleiIoana Berindan-Neagoe
Jul 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reza MohammadinejadAli Zarrabi

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