Abstract
The better understanding of polymeric nanoparticles as a drug delivery carrier is a decisive factor to get more efficient therapeutic response in vivo. Here, we report the non-invasive imaging of bare polymeric nanoparticles and drug-loaded polymeric nanoparticles to evaluate biodistribution in tumor bearing mice. To make nano-sized drug delivery carrier, glycol chitosan was modified with different degrees of hydrophobic N-acetyl histidine (NAcHis-GC-1, -2, and -3). The biodistribution of polymeric nanoparticles and drug was confirmed by using gamma camera with (131)I-labeled NAcHis-GC and (131)I-labeled doxorubicin (DOX) and by using in vivo live animal imaging with near-infrared fluorescence Cy5.5-labeled NAcHis-GC. Among bare nanoparticles, NAcHis-GC3 (7.8% NAcHis content) showed much higher tumor targeting efficiency than NAcHis-GC1 (3.3% NAcHis content) and NAcHis-GC2 (6.8% NAcHis content). In contrast, for drug-loaded nanoparticles, DOX-NAcHis-GC1 displayed two-fold higher tumor targeting property than DOX-NAcHis-GC3. These data imply that the biodistribution and tumor targeting efficiency between bare and drug-loaded nanoparticles may be greatly different. Therapeutic responses for NAcHis-GC nanoparticles after drug load...Continue Reading
References
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Apr 29, 2000·Pharmaceutical Science & Technology Today·G M Barratt
Feb 22, 2001·Nuclear Medicine and Biology·S SamnickC M Kirsch
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MitraA N Maitra
Jun 26, 2003·British Journal of Haematology·Athanasios FassasAchilles Anagnostopoulos
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leyang ZhangYong Hua Yang
Mar 15, 2005·Biomacromolecules·Kwangmeyung KimIn-San Kim
Aug 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Sun ParkYong Woo Cho
Mar 30, 2007·Pharmaceutical Research·Lilian E van VlerkenMansoor M Amiji
Jun 7, 2007·Pharmaceutical Research·Birgit RombergGert Storm
Jul 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyeongsoon ParkIck Chan Kwon
Oct 27, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Jing ZhangCheng Sheng Liu
Jan 19, 2008·Nature Reviews. Cancer·Kevin Brindle
Feb 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jong-Ho KimIck Chan Kwon
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
Citations
Apr 24, 2013·International Journal of Nanomedicine·Wei WangYuangang Zu
Jun 6, 2012·Advanced Drug Delivery Reviews·Tennyson Doane, Clemens Burda
Oct 17, 2014·Nanomedicine·So Jin LeeKwangmeyung Kim
May 23, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Young YheeIck Chan Kwon
Dec 19, 2014·Marine Drugs·Jin-Kyu RheeKyeongsoon Park
Aug 7, 2013·Journal of Drug Targeting·Mohammad MahmoudzadehFarid Dorkoosh
Sep 5, 2012·International Journal of Pharmaceutics·Keun Sang OhSeo Young Jeong
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·So Jin LeeIck Chan Kwon
Sep 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Aug 27, 2014·Angewandte Chemie·Zhuxian ZhouWilliam J Murdoch
Aug 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christin P HollisTonglei Li
Jul 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Won Il ChoiGiyoong Tae
Feb 13, 2013·Carbohydrate Polymers·Thanh Huyen TranKang Moo Huh
Apr 3, 2013·Carbohydrate Polymers·Zheng PanYuping Liu
Dec 3, 2011·Nanoscale·Ki Young ChoiXiaoyuan Chen
Jun 14, 2013·ACS Nano·Pengcheng ZhangHonggang Cui
Aug 20, 2011·Accounts of Chemical Research·Heebeom KooIck Chan Kwon
Sep 23, 2016·Molecular Pharmaceutics·Jin Hee NaKwangmeyung Kim
Oct 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sung Eun KimKyeongsoon Park
Jul 26, 2019·Expert Opinion on Drug Delivery·Yongwhan ChoiKwangmeyung Kim
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fengming LinFu-Gen Wu
Oct 6, 2020·Macromolecular Bioscience·Anna E CaprificoGianpiero Calabrese
Jan 14, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Jihwan SonHeebeom Koo