Tumor targeting efficiency of bare nanoparticles does not mean the efficacy of loaded anticancer drugs: importance of radionuclide imaging for optimization of highly selective tumor targeting polymeric nanoparticles with or without drug

Journal of Controlled Release : Official Journal of the Controlled Release Society
Beom Suk LeeSang Yoon Kim

Abstract

The better understanding of polymeric nanoparticles as a drug delivery carrier is a decisive factor to get more efficient therapeutic response in vivo. Here, we report the non-invasive imaging of bare polymeric nanoparticles and drug-loaded polymeric nanoparticles to evaluate biodistribution in tumor bearing mice. To make nano-sized drug delivery carrier, glycol chitosan was modified with different degrees of hydrophobic N-acetyl histidine (NAcHis-GC-1, -2, and -3). The biodistribution of polymeric nanoparticles and drug was confirmed by using gamma camera with (131)I-labeled NAcHis-GC and (131)I-labeled doxorubicin (DOX) and by using in vivo live animal imaging with near-infrared fluorescence Cy5.5-labeled NAcHis-GC. Among bare nanoparticles, NAcHis-GC3 (7.8% NAcHis content) showed much higher tumor targeting efficiency than NAcHis-GC1 (3.3% NAcHis content) and NAcHis-GC2 (6.8% NAcHis content). In contrast, for drug-loaded nanoparticles, DOX-NAcHis-GC1 displayed two-fold higher tumor targeting property than DOX-NAcHis-GC3. These data imply that the biodistribution and tumor targeting efficiency between bare and drug-loaded nanoparticles may be greatly different. Therapeutic responses for NAcHis-GC nanoparticles after drug load...Continue Reading

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Citations

Jun 6, 2012·Advanced Drug Delivery Reviews·Tennyson Doane, Clemens Burda
May 23, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Young YheeIck Chan Kwon
Dec 19, 2014·Marine Drugs·Jin-Kyu RheeKyeongsoon Park
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·So Jin LeeIck Chan Kwon
Sep 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Aug 27, 2014·Angewandte Chemie·Zhuxian ZhouWilliam J Murdoch
Aug 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christin P HollisTonglei Li
Jul 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Won Il ChoiGiyoong Tae
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Jul 26, 2019·Expert Opinion on Drug Delivery·Yongwhan ChoiKwangmeyung Kim
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Oct 6, 2020·Macromolecular Bioscience·Anna E CaprificoGianpiero Calabrese
Jan 14, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Jihwan SonHeebeom Koo

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