Tumor-triggered transformation of chimeric peptide for dual-stage-amplified magnetic resonance imaging and precise photodynamic therapy

Biomaterials
Jin ZhangHe-You Han

Abstract

Despite the great success in clinical magnetic resonance imaging (MRI), Gd3+-based contrast agents still suffer from low proton relaxation efficiency, rapid metabolic clearance as well as poor sensitivity. In this work, we designed a matrix metalloproteinase-2 (MMP-2) responsive chimeric peptide for dual-stage-amplified MRI and precise photodynamic therapy. Both in vitro and in vivo studies indicated that this chimeric peptide could self-assembly into spherical nanoparticles at physiological condition with r1 value of 28.17 mM-1s-1. Meanwhile, the spherical shape endowed chimeric peptide with efficient tumor accumulation via enhanced penetration and retention (EPR) effect. Importantly, the overexpressed MMP-2 in tumor region could specifically hydrolyze chimeric peptide, leading to sphere-to-fiber transformation. This transformation enhanced both the tumor accumulation and the relaxivity of contrast agent. Consequently, the r1 value was remarkably elevated to 51.52 mM-1s-1, which guided precise photodynamic therapy. This tumor microenvironment-triggered transformable strategy should show great potential for tumor-targeted imaging and phototherapy.

Citations

Feb 16, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Carlo DiaferiaAntonella Accardo
Sep 10, 2020·Advanced Healthcare Materials·Yu DengGaolin Liang
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shabnam TarvirdipourCornelia G Palivan
May 10, 2020·Topics in Current Chemistry·Ashish AvasthiMaría Luisa García-Martín
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Dec 9, 2019·ACS Biomaterials Science & Engineering·Xinxin DaiKai Han
Sep 9, 2021·Nanoscale·Qiaochu JiangXianbao Sun

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