Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor

International Journal of Nanomedicine
Xiaoyu LiJianlin Shi

Abstract

To overcome the drawback of drug non-selectivity in traditional chemotherapy, the construction of multifunctional targeting drug delivery systems is one of the most effective and prevailing approaches. The intratumoral anti-angiogenesis and the tumor cell-killing are two basic approaches in fighting tumors. Herein we report a novel tumor vascular-targeting multidrug delivery system using mesoporous silica nanoparticles as carrier to co-load an antiangiogenic agent (combretastatin A4) and a chemotherapeutic drug (doxorubicin) and conjugate with targeting molecules (iRGD peptide) for combined anti-angiogenesis and chemotherapy. Such a dual-loaded drug delivery system is capable of delivering the two agents at tumor vasculature and then within tumors through a differentiated drug release strategy, which consequently results in greatly improved antitumor efficacy at a very low doxorubicin dose of 1.5 mg/kg. The fast release of the antiangiogenic agent at tumor vasculatures led to the disruption of vascular structure and had a synergetic effect with the chemotherapeutic drug slowly released in the following delivery of chemotherapeutic drug into tumors.

Citations

Nov 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Souvik BanerjeeDuane D Miller
Jul 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gang ZhouJunfeng Zhang
Nov 24, 2019·International Journal of Molecular Sciences·Yu SakuraiHideyoshi Harashima
Jan 16, 2020·International Journal of Molecular Sciences·Anubhab MukherjeeSudip Mukherjee
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gökçe Şeker KaratoprakEduardo Sobarzo-Sánchez
Oct 1, 2019·Current Pharmaceutical Design·Maria R GigliobiancoRoberta Censi
Jun 30, 2019·Current Medicinal Chemistry·Mehdi RajabiShaker A Mousa
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi LiKai Zhao
Jun 21, 2021·Journal of Cancer Research and Clinical Oncology·Ruiqi ZhengAihua Gong
Nov 2, 2019·Biomacromolecules·Jianxun DingXuesi Chen
Sep 12, 2016·ACS Biomaterials Science & Engineering·Scott DavidsonSiddharth V Patwardhan
Apr 21, 2018·Journal of Proteome Research·Yue-Xiao XingJun-Song Wang
Aug 31, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elham SeyyedniaHadi Valizadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.