Tumor volume as a prognostic factor for local control and overall survival in advanced larynx cancer

The Laryngoscope
Adriana J TimmermansMichiel W M van den Brekel

Abstract

Tumor volume has been postulated to be an important prognostic factor for oncological outcome after radiotherapy or chemoradiotherapy. This postulate was retrospectively investigated in a consecutively treated cohort of T3-T4 larynx cancer patients. Retrospective cohort study. For 166 patients with T3-T4 larynx cancer (1999-2008), pretreatment computed tomography and magnetic resonance imaging scans were available for tumor volume delineation. Patients were treated with radiotherapy, chemoradiotherapy, or total laryngectomy with postoperative radiotherapy. Both a dedicated head and neck radiologist and the first author determined all tumor volumes. Statistical analysis was by Kaplan-Meier plots and Cox proportional hazard models. Patients with T3 larynx cancer had significantly smaller tumor volumes than patients with T4 larynx cancer (median = 8.1 cm(3) and 15.8 cm(3), respectively; P < .0001). In the group treated with total laryngectomy and postoperative radiotherapy, no association was found between tumor volume and local or locoregional control or overall survival. In the group treated with radiotherapy, a nonsignificant trend was observed between local control and tumor volume. In the chemoradiotherapy group, however, a s...Continue Reading

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Citations

Dec 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiahuai WenXiaoming Xie
Nov 27, 2016·The Laryngoscope·Philippe GorpheFrançois Janot
Jul 15, 2017·PloS One·Jesper Brandstorp-BoesenKjell Brøndbo
Nov 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereGregory T Wolf
Jul 8, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hongli GongShuyi Wang
Oct 13, 2018·Annals of Surgical Treatment and Research·Ki-Tae HwangDong-Young Noh
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Oct 24, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Natália Martins Magacho de AndradeLuiz Paulo Kowalski
Jan 10, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Meng-Si Luo
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Nov 4, 2021·BMC Bioinformatics·Ayyüce Begüm Bektaş, Mehmet Gönen

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