Tumor volume is a better predictor of post-operative wound complications compared to tumor size in soft tissue sarcomas of the proximal lower extremity

Clinical Sarcoma Research
Michael ZiegeleManpreet Bedi

Abstract

Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rates are comparable to amputation, post-operative wound complications (WC) following limb salvage can result in significant morbidity for the patient. Certain risk factors such as location, pre-operative RT, and age have been shown to increase the risk of WCs. Somewhat surprisingly, size has not consistently been shown to impact WC rates. The goal of this study is to assess whether tumor volume, as opposed to the traditional measurement of the largest dimension in one plane, correlates with the development of post-operative WCs. Between 2000 and 2013, 81 patients with STS of the proximal lower extremity, buttock and pelvis were retrospectively identified from our prospective database. We reviewed the impact of patient, tumor, and treatment variables on postoperative WC. Predictors for WC were evaluated using the Fisher exact test for univariate analysis and logistic regression for multivariate analysis. Tumor volume was determined using the medical image merge (MIM) (®) software program (version 6.5.4, MIM Software, Clevelan...Continue Reading

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Citations

Mar 13, 2018·Clinical Orthopaedics and Related Research·Meena BediJohn C Neilson
Oct 11, 2020·Japanese Journal of Clinical Oncology·Koichi OkajimaSakae Tanaka
Dec 18, 2020·Journal of Surgical Oncology·Yannick A J HoftiezerSantiago A Lozano-Calderón
Dec 10, 2020·Clinical Sarcoma Research·Craig GerrandJeremy Whelan
Nov 26, 2020·Annals of Plastic Surgery·David P PerraultAlex K Wong
May 26, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Johnathan R LexLee M Jeys
Jun 30, 2021·International Wound Journal·Yen-Jen WangChang-Cheng Chang

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Methods Mentioned

BETA
amputation
surgical resection

Software Mentioned

medical image merge ( MIM )
MIM

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