TUmor-volume to breast-volume RAtio for improving COSmetic results in breast cancer patients (TURACOS); a randomized controlled trial

BMC Cancer
M LagendijkLinetta B Koppert

Abstract

Cosmetic result following breast conserving surgery (BCS) for cancer influences quality of life and psychosocial functioning in breast cancer patients. A preoperative prediction of expected cosmetic result following BCS is not (yet) standard clinical practice and therefore the choice for either mastectomy or BCS is still subjective. Recently, we showed that tumour volume to breast volume ratio as well as tumour location in the breast are independent predictors of superior cosmetic result following BCS. Implementation of a prediction model including both factors, has not been studied in a prospective manner. This study aims to improve cosmetic outcome by implementation of a prediction model in the treatment decision making for breast cancer patients opting for BCS. Multicentre, single-blinded, randomized controlled trial comparing standard preoperative work-up to a preoperative work-up with addition of the prediction model. Tumour volume to breast volume ratio and tumour location in the breast will be used to predict cosmetic outcome in invasive breast cancer patients opting for BCS. Three dimensional (3D)-ultrasonography will be used to measure the tumour volume to breast volume ratio needed for the prediction model. Sample siz...Continue Reading

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Citations

Apr 16, 2020·The Breast Journal·Benigno Acea-NebrilJoaquin Mosquera-Oses
Nov 18, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Elvira VosMyriam Hunink
Feb 7, 2021·Surgical Oncology·Sherif MonibHany Habashy
Feb 13, 2021·Diagnostics·Andrea CozziFrancesco Sardanelli
Nov 30, 2021·Breast Cancer Research and Treatment·A T P M Brands-AppeldoornR M H Roumen

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