Tumoral CRP expression in thoracic esophageal squamous cell cancers is associated with poor outcomes.

Surgery Today
Toshinobu NakatsuJun-ichi Ogawa

Abstract

Cancer cells reportedly produce C-reactive protein (CRP) locally within tumors. The aim of this study was to determine whether tumoral CRP is associated with clinical outcome and recurrence in thoracic esophageal squamous cell cancer. The subjects included 73 Japanese patients with thoracic esophageal squamous cell cancer (pathological Stage IIA-IV) that had not been treated preoperatively with either chemotherapy or radiotherapy. Tumoral CRP expression in resected specimens of tumor tissue was assessed by immunohistochemistry. The survival rate following surgery, the rates and patterns of recurrence, and the serum CRP levels before treatment and at recurrence were analyzed in patients with and without tumoral CRP expression. Fifty-nine percent of the study participants (43/73) were positive for tumoral CRP expression, and the remaining 41% (30/73) were negative. No significant difference in clinicopathological factors was observed between the tumoral CRP-positive and CRP-negative groups; however, patients expressing tumoral CRP showed significantly poorer survival and recurrence rates. A multivariate analysis showed that tumoral CRP expression was an independent factor contributing to the likelihood of a poor outcome. Tumoral ...Continue Reading

References

Jul 1, 1986·The Journal of Experimental Medicine·A E Kuta, L L Baum
Feb 17, 2001·Infection and Immunity·J M Gould, J N Weiser
Sep 5, 2001·Molecular Immunology·J E Volanakis
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Feb 21, 2003·European Journal of Immunology·Wolfram J JabsJürgen Steinhoff
Apr 26, 2003·American Journal of Clinical Oncology·Michael G AlexandrakisDespina S Kyriakou
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Thomas P ErlingerKathy J Helzlsouer
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Sep 1, 2004·The Journal of Biological Chemistry·Steven BlackDavid Samols
Jul 28, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P Guillem, J P Triboulet
Oct 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lorraine MarnellTerry W Du Clos
Oct 14, 2005·Kidney International·Wolfram J JabsChristian Doehn
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerAlexander Reinthaller
May 20, 2008·Mutation Research·Joydeb Kumar Kundu, Young-Joon Surh
Nov 18, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Tung NguyenDave S B Hoon

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Citations

May 7, 2013·BMC Cancer·Sandra SteffensAndres J Schrader
Oct 24, 2013·BMC Urology·Andreas Al GhazalAndres J Schrader
Jan 24, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Dae-Eun KimSang-Hee Cho
Oct 19, 2013·Expert Review of Anticancer Therapy·Vinayak Nagaraja, Guy D Eslick
Aug 28, 2015·The Tohoku Journal of Experimental Medicine·Masahiko KitoYukihiro Terada
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Tian-Liang ZhengSong Zhao

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