PMID: 7536789Apr 1, 1995Paper

Tumoricidal response of liver macrophages isolated from rats bearing liver metastases of colon adenocarcinoma

Journal of Leukocyte Biology
C ThomasG L Scherphof

Abstract

Intraportal inoculation of CC531 adenocarcinoma cells into syngeneic rats causes an increase of liver macrophage cell number but not of major histocompatibility complex class II antigen expression. On day 1 after inoculation of 10(5) CC531 cells, a fixed number of isolated liver macrophages lysed significantly more target cells in vitro than did control cells. This effect was still present after 4 weeks. A 10-fold higher initial tumor dose significantly suppressed the macrophage response during the first 2 weeks. In contrast to tumoricidal activity induced by lipopolysaccharide in vitro, the tumoricidal response following in vivo challenge with tumor cells appeared not closely related to the production of reactive nitrogen intermediates, as in the latter case it was not abrogated in the presence of nitric oxide synthase inhibitor. Furthermore, the liver macrophage population appeared not fully activated after tumor inoculation as lipopolysaccharide further increased tumoricidal activity in vitro. The observed numerical and functional response of liver macrophages to intraportally inoculated tumor cells points at an important role of these cells in aspecific immune reactivity aimed at the reduction of local tumor growth. Results...Continue Reading

Citations

Sep 19, 2014·International Journal of Oncology·Hideki MatsumuraNobuhiro Ohkohchi
Jan 1, 1996·Toxicologic Pathology·E WisseA Vermoesen
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Maarten TimmersFilip Braet
Nov 5, 2002·Critical Reviews in Oncology/hematology·A H KlimpT Daemen
Jun 14, 2000·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·P A BrennanG A Zaki
Jul 1, 1996·Journal of Hepatology·K P de JongO T Terpstra

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