PMID: 6161207Jan 1, 1981Paper

Tumorigenicity and lysis by natural killers

The Journal of Experimental Medicine
J L CollinsM Cohn

Abstract

Detailed analysis of the natural killer (NK) activity directed at nontumorigenic cell lines and their transformed tumorigenic derivatives has revealed a paradox. On the one hand, a correlation has been found between the tumorigenic potential of chemically transformed fibroblast cell lines and their sensitivity to NK cells in vitro. Nontransformed cells (N-type cell lines) and cells tumorigenic in normal mice (C-type cell lines) are resistant to NK-mediated lysis. In contrast, cell lines that are tumorigenic in ATxFL mice (these mice are very low in NK activity), but not in normal mice (I-type cell lines) are sensitive to NK-mediated lysis. These findings support the concept that NK activity is involved in host surveillance against tumors. On the other hand, NK-resistant fibroblasts, whether taken directly form animals or derived as tumorigenic or nontumorigenic cell lines, compete with NK-sensitive target cells to inhibit their lysis by NK effectors. Not only are both NK-sensitive and -resistant cells recognized by NK effectors but both receive lytic signals from NK effector cells. Target cell resistance is a result of a protein synthesis-dependent mechanism that prevents lysis such that in the presence of inhibitors of protein...Continue Reading

Citations

Jan 1, 1990·Clinical & Experimental Metastasis·P W JohnsonJ C Roder
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·M ShibuyaM Ohtsuka
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·C B PowellJ L Collins
Sep 1, 1983·Clinical Rheumatology·R D Armstrong, G S Panayi
Jan 1, 1982·Springer Seminars in Immunopathology·B Rager-Zisman, B R Bloom
Feb 16, 2005·Springer Seminars in Immunopathology·Melvin Cohn
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J C RoderD Kozbor
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W Newman
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D P DubeyR Sager
Nov 1, 1985·Pathology, Research and Practice·A Boekstegers, E Grundmann
Dec 1, 1982·American Journal of Reproductive Immunology : AJRI·M C Simmler, P R Avner
Oct 1, 1988·Scandinavian Journal of Immunology·J BaenzigerP Groscurth
Aug 15, 1983·International Journal of Cancer. Journal International Du Cancer·I KimberK Roberts
Mar 15, 1985·International Journal of Cancer. Journal International Du Cancer·J S FosterA T Ichiki
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·J L CookA M Lewis
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·N E Kay
Oct 1, 1982·Journal of Clinical Immunology·J C Roder, H F Pross
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·W E Vanderslice, J L Collins
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·D A Chow
Mar 15, 1985·International Journal of Cancer. Journal International Du Cancer·G W Brown, D A Chow
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·D A ChowA H Greenberg
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·E C LattimeO Stutman
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·G E PiontekH Hengartner
Apr 1, 1985·American Journal of Hematology·A Schattner, D B Duggan
Jun 15, 1983·International Journal of Cancer. Journal International Du Cancer·R Hentschel, E Kölsch
Nov 11, 1983·Science·L V Abruzzo, D A Rowley

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