Tumorigenicity of cerebellar primitive neuro-ectodermal tumors in athymic mice correlates with poor prognosis in children

International Journal of Cancer. Journal International Du Cancer
G VassalA Gouyette

Abstract

The histogenesis of medulloblastoma, also described as a cerebellar primitive neuro-ectodermal tumor (PNET), remains controversial and unresolved. In addition, genetic markers which characterize cerebellar PNETs with poor prognosis in children have not been identified. Since xenografts can be valuable tools for better understanding the genetic events involved in cerebellar PNETs, small fragments of tumor samples from 17 children with newly diagnosed cerebellar PNETs were transplanted s.c. into female athymic Swiss mice. Eleven were non-metastatic and 6 were metastatic PNETs. Eight tumors (47%) were tumorigenic. Histological analysis showed 6 typical medulloblastomas, 1 PNET with melanin pigment and 1 PNET with a rhabdoid phenotype. Wide heterogeneity was observed in tumor growth, with a doubling time ranging from 8 to 81 days after the first passage. Tumorigenicity was correlated with the metastatic phenotype of the tumor (p < 0.001). All the patients but one with a tumorigenic tumor relapsed and died. The survival of patients with a non-tumorigenic PNET (67%) was significantly higher than that of patients with a tumorigenic PNET (13%) (p < 0.02). None of the xenografts or tumors from patients exhibited N-myc-gene alteration. O...Continue Reading

References

Sep 1, 1977·International Journal of Radiation Oncology, Biology, Physics·L Harisiadis, C H Chang
Sep 1, 1990·Brain Pathology·S H Bigner, B Vogelstein
Aug 1, 1991·Journal of Neuro-oncology·H S FriedmanD D Bigner
Jan 1, 1990·Annals of the New York Academy of Sciences·N M Le Douarin
Sep 15, 1989·International Journal of Cancer. Journal International Du Cancer·L Bettan-RenaudJ Benard
Nov 1, 1988·Cancer Metastasis Reviews·J MatternM Volm
Jan 1, 1981·Clinical Neurology and Neurosurgery·S J DuinkerkeJ H Biesta
Sep 1, 1983·The American Journal of Surgical Pathology·C M CoffinL P Dehner
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M SchwabJ M Bishop
Jan 1, 1983·Experimental Cell Biology·J E NeelyL Workman
Jan 1, 1995·Journal of Neuro-oncology·S K BatraS H Bigner

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Citations

Aug 9, 2005·Pediatric Blood & Cancer·Nathalie GasparGilles Vassal
Feb 4, 1999·Annals of Diagnostic Pathology·J C Fanburg-SmithM Miettinen
Nov 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Laura SanzLuís Alvarez-Vallina
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·G VassalA Gouyette

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