Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

Biomaterials
Wen-Chia HuangHsin-Cheng Chiu

Abstract

Overcoming limitations often experienced in nanomedicine delivery toward hypoxia regions of malignant tumors remains a great challenge. In this study, a promising modality for active hypoxia drug delivery was developed by adopting tumortropic monocytes/macrophages as a cellular vehicle for co-delivery of echogenic polymer/C5F12 bubbles and doxorubicin-loaded polymer vesicles. Through the remote-controlled focused ultrasound (FUS)-triggered drug liberation, therapeutic monocytes show prominent capability of inducing apoptosis of cancer cells. The in vivo and ex vivo fluorescence imaging shows appreciable accumulation of cell-mediated therapeutics in tumor as compared to the nanoparticle counterpart residing mostly in liver. Inhibition of tumor recurrence with γ-ray pre-irradiated Tramp-C1-bearing mice receiving therapeutic monocytes intravenously alongside the FUS activation at tumor site was significantly observed. Immunohistochemical examination of tumor sections confirms successful cellular transport of therapeutic payloads to hypoxic regions and pronounced cytotoxic action against hypoxic cells. Following the intravenous administration, the cellular-mediated therapeutics can penetrate easily to a depth beyond 150 μm from the...Continue Reading

References

Mar 1, 1995·Journal of Microencapsulation·S P VyasR K Asati
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaT Konno
May 9, 2003·Nature·Philippe Marmottant, Sascha Hilgenfeldt
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Dec 14, 2004·The Oncologist·Peter Vaupel, Louis Harrison
Aug 30, 2005·The American Journal of Pathology·Claire Lewis, Craig Murdoch
Nov 22, 2005·Expert Opinion on Drug Delivery·William G PittBryant J Staples
Mar 2, 2006·Journal of the National Cancer Institute·Matthew R DreherAshutosh Chilkoti
Apr 6, 2006·Advances in Experimental Medicine and Biology·Peter VaupelMichael Höckel
Nov 1, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·David ZagzagElizabeth W Newcomb
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Chien-Sheng TsaiJi-Hong Hong
May 4, 2007·The Journal of Clinical Investigation·Antonio Sica, Vincenzo Bronte
Jan 8, 2008·Current Opinion in Immunology·Li ZhangGeorge S Eisenbarth
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Mar 29, 2008·Gene Therapy·J C RothL Pereboeva
Dec 17, 2009·Cytokine & Growth Factor Reviews·Alberto MantovaniRaffaella Bonecchi
Feb 13, 2010·International Journal of Radiation Biology·Won Hee LeeYong Woo Lee
Jun 3, 2010·Molecular Cancer Therapeutics·Tina D TailorMark W Dewhirst
Dec 15, 2010·Advanced Drug Delivery Reviews·Michael K DanquahRam I Mahato
May 31, 2011·International Journal of Radiation Oncology, Biology, Physics·Fang-Hsin ChenJi-Hong Hong
Sep 7, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shu-Chi WangChi-Shiun Chiang
Oct 8, 2011·Annals of Biomedical Engineering·Steen J MadsenHenry Hirschberg
Nov 5, 2011·Journal of Drug Targeting·Wen-Chia HuangHsin-Cheng Chiu
Dec 7, 2011·Biomaterials·Chung-Hsin WangChih-Kuang Yeh
Mar 9, 2012·Biomaterials·Jinhyang ChoiEun Kyung Choi
Apr 3, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael MilosevicRobert Bristow
Aug 14, 2012·Frontiers in Oncology·Chi-Shiun ChiangJi-Hong Hong
Feb 6, 2013·Theranostics·Steven P WrennPeter A Lewin
Mar 6, 2013·International Journal of Nanomedicine·Hongkee SahGeorge C Wood

❮ Previous
Next ❯

Citations

Mar 16, 2016·Stem Cells International·Elena CodriciCristiana Tanase
Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yihua Pei, Yoon Yeo
Sep 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wen-Chia HuangHsin-Cheng Chiu
May 28, 2016·Pharmaceutical Research·Mihaela AldeaIoan Stefan Florian
Sep 23, 2016·Chemical Reviews·Gaixia XuParas N Prasad
Feb 16, 2017·Journal of Cellular Physiology·Rana Jahanban-EsfahlanBahman Yousefi
Jan 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seok-Beom YongYong-Hee Kim
Jan 16, 2018·Advanced Healthcare Materials·Jiayu LeongHyunjoon Kong
Mar 16, 2018·Chemistry : a European Journal·Bishnu P JoshiMichelle E Farkas
Nov 5, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Helen MulvanaEleanor Stride
Nov 28, 2017·Nanomedicine·Chao WangXiao Chen
Oct 29, 2018·Advanced Materials·Weizhong ZhangJin Xie
Dec 7, 2018·Cancer Chemotherapy and Pharmacology·Huangliang ZhengYihui Deng
Mar 27, 2019·Therapeutic Delivery·Steen J Madsen, Henry Hirschberg
Feb 12, 2019·Frontiers in Pharmacology·Johan Georg VisserCarine Smith
Oct 21, 2018·Pharmaceutics·Yu-Lin Su, Shang-Hsiu Hu
Dec 7, 2019·Molecular Cancer·Xiaolei LiYufang Shi
Dec 18, 2020·Advanced Healthcare Materials·Junhee ChoiHongsoo Choi
Sep 14, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Jake C ForsterEva Bezak
Sep 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZhangFeng Lv
Sep 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Weishuo LiCan Zhang
Apr 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hung V Nguyen, Vincent Faivre
Sep 27, 2020·Current Opinion in Pharmacology·Marie Pierre Krafft
Jun 15, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·John D MartinHoracio Cabral
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Jan 1, 2020·ACS Applied Materials & Interfaces·Chao PengYingjia Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Advances in Experimental Medicine and Biology
Youssef W Naguib, Zhengrong Cui
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Andrew J PrimeauIan F Tannock
© 2021 Meta ULC. All rights reserved