Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast

The Journal of Pathology
G MorphopoulosM Harris

Abstract

The importance of angiogenesis, assessed by tumour microvessel density, as a marker of survival was examined in 160 patients with infiltrating lobular carcinoma of the breast (ILC). The median follow-up was 5.1 years. Of these patients, 46 were node-negative, 59 were node-positive, and in 55 the pathological lymph node status was not known. Tumour sections were immunohistochemically stained with Factor VIII-related antibody. Microvessels were identified using previously recommended methodology and counted in three separate fields, selected from areas of highest vascularity, at x 200 magnification (field area = 0.785 mm2). Only the highest count was considered in the analysis. No association was found between microvessel density and age, menopausal status, tumour size, histological subtype, peritumoural vessel invasion, and lymph node involvement at presentation. There was no association between microvessel density and overall survival or relapse-free survival. These results suggest that microvessel density assessment, using currently recommended methods, is unlikely to be of prognostic value in ILC.

References

Nov 1, 1979·Histopathology·V Martinez, J G Azzopardi
Dec 16, 1992·Journal of the National Cancer Institute·D L Page, W D Dupont
Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jul 1, 1992·Human Pathology·S BosariM L Silverman
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jan 1, 1990·The American Journal of Surgical Pathology·D DiCostanzoM Lesser
Oct 1, 1989·British Journal of Cancer·R S du ToitR W Blamey
Mar 1, 1982·Histopathology·J M DixonS W Duffy
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G GaspariniF Pozza
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K MaedaY Arimoto
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Gasparini, A L Harris
Aug 12, 1995·Lancet·L M Ellis, I J Fidler
Jul 5, 1995·Journal of the National Cancer Institute·K AxelssonB H Mayall
Aug 12, 1995·Lancet·P J Harrison
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·M ToiT Tominaga
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·G GaspariniP Bevilacqua
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E Van HoefA M Schor

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Citations

Dec 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J AhlgrenJ Bergh
Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Oct 27, 2007·Scandinavian Journal of Gastroenterology·Madoka NakaoKazuaki Chayama
Apr 19, 2002·Current Problems in Cancer·George W Sledge, Kathy D Miller
Oct 12, 2004·Hematology/oncology Clinics of North America·Kathy D Miller, Carrie L Dul
Sep 1, 1996·The Journal of Pathology·R A Walker
Jun 27, 2002·British Journal of Cancer·J HasanG C Jayson
Oct 13, 2006·Breast Cancer Research and Treatment·Gary M K TseHumairah S Cheung
May 18, 1999·Breast Cancer Research and Treatment·P SalvenH Joensuu
Mar 5, 1999·Breast Cancer Research and Treatment·I C Henderson, A J Patek
Jan 26, 2000·British Journal of Cancer·S HansenC Rose
Apr 3, 1998·Annals of Surgical Oncology·N C SaenzM F Brennan
Feb 13, 2001·Critical Reviews in Oncology/hematology·G Gasparini

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