PMID: 2444545Oct 1, 1987Paper

Tumour bed effect: hypoxic fraction of tumours growing in preirradiated beds

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
M PenhaligonR S Camplejohn

Abstract

The reduction in tumour growth rate seen when tumours are implanted into preirradiated sites, the tumour bed effect (TBE), is believed to be due to radiation damage to vascular stroma, leading to defective angiogenesis in the tumour. The present work examined whether or not the functional inadequacy of irradiated stroma was accompanied by an increased hypoxic fraction in tumours growing in irradiated beds. Mouse flank skin was given 0 or 20 Gy X-rays and RIF-1 fibrosarcoma cells were implanted i.d. into the centre of the treatment field one week later. Tumours of 200 mm3 were irradiated under clamped or unclamped conditions and the hypoxic fraction measured from the displacement of the corresponding survival curves, assayed in vitro. Results indicated a small increase in the hypoxic fraction. Averaging values from three independent experiments, the percentage of hypoxic cells increased from 2.5 per cent for cells in tumours growing in unirradiated beds to 4.6 per cent for those from tumours in beds given 20 Gy. Thus an irradiated vascular bed is still to some extent able to maintain the proportion of oxic: hypoxic tumour cells found in tumours growing in unirradiated beds, despite manifest changes in tumour necrosis and growth ...Continue Reading

References

May 1, 1985·The British Journal of Radiology·R S Camplejohn, M Penhaligon
Mar 1, 1971·The Journal of Hygiene·P Armitage
Dec 1, 1968·British Journal of Cancer·H B Hewitt, E R Blake
Aug 1, 1983·The British Journal of Radiology·A C Begg, N H Terry
May 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J E Moulder, S Rockwell
Nov 1, 1982·The British Journal of Radiology·K R Trott, J Kummermehr

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Citations

May 14, 2010·Journal of the National Cancer Institute·Olaf PenackMarcel R M van den Brink
Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·K H Falkvoll
Jun 26, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·François KuonenCurzio Rüegg
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·François KuonenCurzio Rüegg

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