Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro-oesophageal junction cancers

Histopathology
Matthew BrownSusan A Pritchard

Abstract

Tumour budding and host inflammatory response are parameters easily assessed histologically that have prognostic significance in many cancers. There have been few studies examining these parameters in oesophageal or gastro-oesophageal cancers. This study aims to address that deficiency. A two-centre, retrospective study was carried out on 356 patients. Tumour budding and host inflammatory response at the invasive front were assessed histologically. Statistical analysis was performed to determine the prognostic significance of these factors. The median number of tumour buds was four (range 0-50) with 172 of 356 cases having five or more buds at the invasive front. The presence of five or more buds was associated with a poor prognosis on univariate analysis (P = 0.0001), as was a sparse or moderate host inflammatory response (P = 0.001). Tumour budding retained prognostic significance when tumours were separated into adenocarcinomas (n = 287) and squamous cell carcinomas (n = 69), but host inflammatory response was a significant prognostic factor only for adenocarcinomas. On multivariate analysis the presence of five or more buds retained significance (P = 0.002). Tumour budding and host inflammatory response are important progno...Continue Reading

References

Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·H E GabbertG Hommel
Jan 1, 1985·Cancer Metastasis Reviews·H Gabbert
Jul 1, 1993·Diseases of the Colon and Rectum·K HaseM Vierra
May 21, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y MaS Okada
Feb 8, 2003·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel Rohan, Stanislav Komenda
Oct 9, 2003·Alimentary Pharmacology & Therapeutics·M R B Keighley
Oct 20, 2004·Annals of Surgery·Hideki UenoIan C Talbot
Dec 1, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M S RohP J Choi
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jan 6, 2007·Histopathology·F Prall
Oct 16, 2008·The American Journal of Gastroenterology·Côme LepageMichel P Coleman

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Citations

Dec 14, 2012·World Journal of Gastroenterology : WJG·Fabio GrizziLuigi Laghi
Apr 26, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael S LandauJon M Davison
Oct 18, 2011·Expert Review of Anticancer Therapy·Bruno Märkl, Hans M Arnholdt
Oct 8, 2013·Expert Opinion on Medical Diagnostics·Patrick S PlumUte Warnecke-Eberz
Mar 17, 2016·Human Pathology·Svenja ThiesRupert Langer
Jul 18, 2015·Histopathology·Alhadi AlmangushIlmo Leivo
Nov 28, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E KaramitopoulouA Lugli
Feb 27, 2014·Clinical Endoscopy·Andrea Grin, Catherine J Streutker
Apr 13, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cheng WangXiqiang Liu
Aug 26, 2011·International Journal of Cancer. Journal International Du Cancer·Ole Didrik LaerumMartin Illemann
Jun 6, 2014·Histopathology·Alhadi AlmangushIlmo Leivo
Sep 2, 2014·Frontiers in Oncology·Viktor H KoelzerAlessandro Lugli
May 3, 2016·Journal of Clinical Medicine·Alexandru Dan GrigoreHerbert Levine
Sep 7, 2016·British Journal of Cancer·A C RogersK Sheahan
Mar 2, 2018·Histopathology·Eva KaramitopoulouAlessandro Lugli
May 15, 2018·British Journal of Cancer·Philipp LohneisAnja Jühling
Sep 10, 2020·Nature Reviews. Clinical Oncology·Alessandro LugliIris D Nagtegaal
Sep 3, 2020·Annals of the New York Academy of Sciences·Esmeralda Celia Marginean, Jain Dhanpat
Sep 7, 2020·Annals of the New York Academy of Sciences·Xuchen Zhang, Dhanpat Jain
Apr 26, 2015·International Journal of Surgical Pathology·Mine GulluogluEmre Balik
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Yi-Xian GuoEn-Hao Zhao
Jul 26, 2011·Virchows Archiv : an International Journal of Pathology·Keita KaiHirokazu Noshiro
Jan 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M Priyanthi KumarasingheGregory Y Lauwers
Dec 15, 2018·Journal of Surgical Oncology·Nobuhiro YamakawaUNKNOWN Japan Oral Oncology Group (JOOG)
Nov 11, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lanqing CaoLijuan Wei
Aug 18, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Kazuya HaraguchiKazuhiro Tominaga
Feb 26, 2021·Frontiers in Molecular Biosciences·Kate DinneenOrla Sheils
Aug 1, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Rhiannon McShaneMark Bates

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