PMID: 8605094Mar 1, 1996Paper

Tumour cells surviving in vivo cisplatin chemotherapy display elevated c-myc expression

British Journal of Cancer
T L WalkerE E DeCruz

Abstract

The c-myc oncogene has been extensively implicated in cell proliferation, cell differentiation and programmed cell death. Aberrant expression of the c-myc gene product has been observed in a range of tumours and has also been implicated in cisplatin (cis-dichlorodiammineplatinum)-mediated chemoresistance. A solid transplantable tumour model in syngeneic DA rats was subjected to treatment with cisplatin to determine the impact of such therapy on endogenous c-myc gene expression. Serially transplanted tumours were intravenously treated with a single cisplatin dose (1 mg/kg) and c-myc expression analysed 2 and 7 days after treatment. The surviving tumour cells display a significant 2-fold elevation in c-myc expression at 48 h and 7 days after treatment. Primary cell cultures have been derived from untreated in vivo tumours of the same model and subjected to treatment with a c-myc phosphorothioate antisense oligomer. Administration of 5 microM c-myc antisense oligomer directed at the initiation codon and first four codons of c-myc mRNA results in total inhibition of c-myc expression and coincident suspension of cell growth for a period of 4 days in culture. Antisense therapies directed at the c-myc gene may well prove an effective ...Continue Reading

Citations

Dec 12, 2012·Cancer Chemotherapy and Pharmacology·Kosuke OkadaToru Yanagawa
Feb 18, 2015·Journal of Cellular and Molecular Medicine·Naruji KugimiyaKimikazu Hamano
Jun 10, 2018·The Journal of Pathology·Christina AlidoustyAnne Maria Schultheis
Sep 1, 1999·The Journal of Pharmacy and Pharmacology·C R Dass, M A Burton
Aug 29, 2007·Acta Pharmacologica Sinica·Fazlul H Sarkar, Yi-wei Li
Jun 8, 2017·Genes·Alpana KumariDaitoku Sakamuro
Jul 4, 2018·Frontiers in Oncology·Jens C Hahne, Nicola Valeri
May 20, 2019·International Journal of Hematology·Taisuke NarazakiYoshihiro Ogawa
Aug 1, 2015·Molecular Cancer Therapeutics·Jeyshka M Reyes-GonzálezPablo E Vivas-Mejía
Apr 2, 1998·Journal of Pharmaceutical Sciences·T L WalkerM A Burton
Aug 28, 2021·Biomedicines·Ekaterina Mikhailovna StasevichAnton Markovich Schwartz

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