journal cover

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

Nature Cell Biology

Nov 4, 2019

Goncalo RodriguesDavid C Lyden

Get paper from

Abstract

The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-condit...read more

Mentioned in this Paper

Brain
Inflammation
Lung
Neoplasms
Tumor Necrosis Factors
Up-Regulation (Physiology)
Cytokine
B-Cell Lymphomas
Prophylactic Treatment
Branching (Qualifier Value)
187
8
3
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Stem Cell Niches

Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Chemoproteomics

Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. Here is the latest research on this chemical proteomic method for pharmacological discovery research.

Microglia And CNS Diseases

Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Imaging Mass Spectrometry

Imaging mass spectrometry enables the visualization and assessment of the spatial distribution of molecules, including biomarkers and metabolites, based on their molecular mass. Here is the latest research.

Respiratory: Allergy, Immunology & Inflammation

This feed has been developed in conjunction with the American Thoracic Society for the benefit of its Allergy, Immunology, and Inflammation Assembly. It highlights new and impactful papers on allergy, asthma, genetics, and the pathogenesis of lung diseases.

Neuroinflammation

Neuroinflammation is a defensive response, characterized by the activation of proinflammatory molecules including microglia and astrocytes. The response has been implicated in brain injuries, acute and chronic neurological and neurodegenerative disorders such as Alzheimer’s disease. Here is the latest research on neuroinflammation.

Lymphoma, B-Cell

B-Cell Lymphoma includes types of lymphomas that affect B cells. Here is the latest research on B-Cell lymphoma.

Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

© 2019 Meta ULC. All rights reserved

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

Nature Cell Biology

Nov 4, 2019

Goncalo RodriguesDavid C Lyden

PMID: 31685984

DOI: 10.1038/s41556-019-0404-4

Abstract

The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-condit...read more

Mentioned in this Paper

Brain
Inflammation
Lung
Neoplasms
Tumor Necrosis Factors
187
8
3

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/tumour-exosomal-cemip-protein-promotes-cancer/31685984