Tumour growth after portal vein embolization with pre-procedural chemotherapy for colorectal liver metastases

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Lidewij SpeltChristian Sturesson

Abstract

For resection of colorectal cancer (CRC) liver metastases, pre-operative portal vein embolization (PVE) is used to increase the size of the future liver remnant (FLR) prior to advanced liver resection when indicated. PVE is speculated to cause tumour progression, but only a limited number of studies have analysed tumour growth after PVE in the context of pre-procedural chemotherapy, which was the aim of this retrospective study. Patients treated with stabilizing chemotherapy and PVE before liver resection for CRC metastases were included. Tumour progression according to RECIST guidelines and a change in tumour volume was analysed on computed tomography (CT) scans prior to chemotherapy, before PVE and after PVE, respectively. Thirty-four patients were included, of whom 23 had bilobar disease. Of tumours in the embolized lobe, 3/34 showed progression after PVE as compared with 3/23 in the non-embolized lobe (P = 0.677). A decrease in tumour volume of 16% and 11% was noted in the embolized and non-embolized lobe, respectively (P = 0.368). Patients were off chemotherapy in a median of 16 days before PVE. There was a linear correlation between the growth of tumours and time between the end of chemotherapy and PVE (r = 0.25, P = 0.00...Continue Reading

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Citations

Aug 8, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Christian SturessonInger Keussen
Mar 2, 2019·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Lorenz BiggemannAli Seif Amir Hosseini
Aug 3, 2017·World Journal of Gastroenterology : WJG·Silvio Marcio Pegoraro BalzanMarcelo Luiz Dotto

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