PMID: 9187300May 17, 1997Paper

Tumour growth modifies intravascular polyamine transport by plasma lipoproteins in the mouse

Biochimica Et Biophysica Acta
V Catros-QuemenerJ Chapman

Abstract

Polyamines are polycationic compounds which are implicated in cell division and tumor growth. We have evaluated the potential role of plasma lipoproteins in the transport of major polyamines, spermine, spermidine and putrescine, and the effect of tumor growth on such transport. Plasmas of healthy male BL6/DBA2 mice and of mice bearing Lewis lung carcinoma (3LL) were fractionated by isopycnic density gradient ultracentrifugation, and polyamine content determined in lipoprotein fractions. Spermidine was the most abundant polyamine in the lipoproteins of both control and tumor-bearing mice and was principally associated with HDL (d: 1.046-1.136 g/ml); approx. 40% of total plasma polyamines was lipoprotein-associated in control mice and 60% in cancerous mice. Only minor amounts were transported by LDL (< 10% of total lipoprotein-associated polyamines), while VLDL were devoid of these substances. Marked elevations of circulating levels of LDL were found in 3LL grafted mice: in these particles however, the contents of spermidine and spermine were significantly reduced. A preferential uptake of polyamines by red blood cells could in part explain this marked reduction of LDL polyamine content, but the consequence of this reduction on t...Continue Reading

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Citations

May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Gugliucci
Sep 11, 2002·The Journal of Nutrition·Dongmei SunAlison M Stephen

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