Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination

Royal Society Open Science
Adrien HallouAlexandre J Kabla

Abstract

Heterogeneity within tumour cell populations is commonly observed in most cancers. However, its impact on metastatic dissemination, one of the primary determinants of the disease prognosis, remains poorly understood. Working with a simplified numerical model of tumour spheroids, we investigated the impact of mechanical heterogeneity on the onset of tumour invasion into surrounding tissues. Our work establishes a positive link between tumour heterogeneity and metastatic dissemination, and recapitulates a number of invasion patterns identified in vivo, such as multicellular finger-like protrusions. Two complementary mechanisms are at play in heterogeneous tumours. A small proportion of stronger cells are able to initiate and lead the escape of cells, while collective effects in the bulk of the tumour provide the coordination required to sustain the invasive process through multicellular streaming. This suggests that the multicellular dynamics observed during metastasis is a generic feature of mechanically heterogeneous cell populations and might rely on a limited and generic set of attributes.

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Jun 28, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L-L DengY Yang
Jun 27, 2019·Journal of Clinical Medicine·Sugandha BhatiaErik W Thompson
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Mar 25, 2019·Bulletin of Mathematical Biology·Linnea C FranssenMark A J Chaplain
Sep 7, 2019·Physical Review Letters·Xinzhi LiDapeng Bi

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