Tumour histological grade may progress between primary and recurrent invasive mammary carcinoma

Journal of Clinical Pathology
G Cserni

Abstract

To assess the constancy of the histological grade of invasive breast carcinomas by comparing primary tumours with their axillary metastases and local or regional recurrences. Eighty four recurrent invasive breast carcinomas with a primary tumour or previous recurrence were available for histological review from the period 1980 to 2000. These and any further recurrences were graded by one observer. Nine, 24, and 51 tumours with grades 1, 2, and 3, respectively, recurred. Grade 1, 2, and 3 tumours recurred within a median time of 88, 42, and 23 months, respectively. The intraobserver reproducibility of the histological grade was good (kappa = 0.66), and the grades of the primary tumours and their axillary metastases or next recurrence also exhibited good agreement. However, when further (second to sixth) recurrences were included in the analysis, the agreement between the grade of the tumours and their last recurrence was only moderate (kappa = 0.48). Only two of the nine grade 1 and 15 of the 24 grade 2 tumours retained their grade in their last recurrence. Low grade carcinomas require a longer follow up. These long term data support the possibility of a transition from low grade invasive breast carcinomas to higher grade tumour...Continue Reading

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Citations

Jan 13, 2011·Breast Cancer Research and Treatment·Julia KravchenkoH Kim Lyerly
Feb 6, 2004·Breast Cancer Research and Treatment·Marc Lacroix, Guy Leclercq
Aug 29, 2003·Journal of Clinical Pathology·T J AndersonUNKNOWN Scottish Breast Pathology Coordination Group
Jul 20, 2006·Breast Cancer Research and Treatment·Guillermo CarreñoFrancisco J Vizoso
Feb 22, 2012·Journal of Medical Imaging and Radiation Oncology·Carmen J HansenJarad Martin
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis
Sep 16, 2003·Advances in Anatomic Pathology·Stanley E Shackney, Jan F Silverman
Dec 5, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jianfang ZengKeng Shen
Nov 30, 2019·Pathology Oncology Research : POR·Gábor Cserni, Anita Sejben
Mar 30, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha RekhtmanWei-Chu Lai

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