Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer

Theranostics
Mengmeng SunWeiping Gao

Abstract

Near-infrared (NIR)-absorbing conjugated polymer nanoparticles are interesting for imaging-guided combination therapy, especially for synergistic photothermal therapy and chemotherapy; however, most of them target tumours passively through the enhanced permeability and retention (EPR) effect, leading to low utilization efficiency. To address this problem, we report an active tumour-targeting strategy of tumour-homing chimeric polypeptide-conjugated NIR-absorbing conjugated-polymer nanoparticles as a new class of drug nanocarriers for imaging-guided combination therapy of cancer. Methods: A tumour-homing chimeric polypeptide C-ELP-F3 was genetically engineered, and chemoselectively conjugated to polypyrrole (PPy) nanoparticles via a facile thiol-maleimide coupling reaction to form ELP-F3 conjugated PPy (PPy-ELP-F3) nanoparticles. Doxorubicin (DOX) was physically adsorbed onto PPy-ELP-F3 nanoparticles to yield DOX-loaded PPy-ELP-F3 (DOX/PPy-ELP-F3) nanoparticles. The physicochemical properties of DOX/PPy-ELP-F3 were characterized. The pharmacokinetics of DOX/PPy-ELP-F3 was studied in a mouse model. The photoacoustic imaging and photothermal imaging of tumours were tested in a melanoma-bearing mouse model. The photothermal-chemica...Continue Reading

Citations

Oct 24, 2019·Current Topics in Medicinal Chemistry·Congcong ZhuQuangang Zhu
May 29, 2020·Journal of Receptor and Signal Transduction Research·Nan ZhengDongkai Shan
Feb 28, 2021·Colloids and Surfaces. B, Biointerfaces·Liwen FuChuanglong He
Apr 23, 2021·Macromolecular Bioscience·Liwen FuChuanglong He
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vijay Sagar MadamsettySudip Mukherjee

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Methods Mentioned

BETA
electrophoresis
fluorescence-activated cell sorting
fluorescence imaging
transmission electron microscopy
irradiate

Software Mentioned

Softmax

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