PMID: 9657662Jul 10, 1998Paper

Tumour-infiltrating lymphocytes in non-small cell lung cancer are activated T lymphocytes

Respirology : Official Journal of the Asian Pacific Society of Respirology
S H KuoK T Luh

Abstract

This study was carried out in order to investigate the local immune reaction of tumour-infiltrating lymphocytes (TILs) in the primary tumours of non-small cell lung carcinomas. Thirty non-small cell lung cancer (NSCLC) patients were included. The tumour tissue was taken at thoracotomy and monocellular suspension of the tumour was obtained by mechanical disaggregation. Dual-coloured flow cytometric analysis of TILs and their corresponding peripheral blood lymphocytes (PBLs) was performed. Tumour-infiltrating lymphocytes contained significantly higher proportions of CD3(+) T lymphocytes and CD8(+) T lymphocytes than the corresponding PBLs (82.0%+/-13.9% vs 66.3%+/-10.6% for CD3, P<0.001; 39.0%+/-18.4% vs 26.4%+/-5.2% for CD8, P<0.001). Tumour-infiltrating lymphocytes contained significantly higher proportions of activated memory lymphocytes than PBLs did (9.8%+/-8.6% vs 1.3%+/-1.5% for CD25, P<0.001; 40.5%+/-30.2% vs 10.2%+/-14.8% for CD71, P<0.001; 75.5%+/-11.9% vs 28.6%+/-9.8% for HLA-DR, P<0.001). These findings were also found in both CD4(+) TILs and CD8(+) TILs. The TILs of NSCLC contained higher proportions of T lymphocytes and CD8(+) lymphocytes than their corresponding peripheral bloods. The proportions of activated memor...Continue Reading

Citations

Sep 1, 2011·Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : časopis Društva Za Medicinsku Informatiku BiH·Edin JusufovicEkrem Ajanovic
Dec 22, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roy M BremnesLill-Tove Busund
May 19, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Khalid Al-ShibliLill-Tove Busund
Jun 28, 2014·Molecular Biology Reports·Junying Wang, Xueju Wang
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillaume DorothéeFathia Mami-Chouaib
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khalid I Al-ShibliLill-Tove Busund

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