Tumour metastasis: is tissue an issue?

The Lancet Oncology
D J RuiterR M de Waal

Abstract

Single tumour cells, or multicellular aggregates, escape into blood and lymphatic vessels from a primary solid tumour as it progresses. However, the ability of such cells to develop into metastatic outgrowths is very limited, as shown by the poor prognostic power of the presence of circulating tumour cells in cancer patients. An explanation for this low efficiency may be a temporary absence of a suitable microenvironment once the tumour cells escape from their original tissue compartment. On the basis of histopathological observations, experimental studies, and the generally accepted poor prognosis of histopathologically confirmed intravascular tumour location, we propose that the structural and functional organisation of intravascular tumour cells as a tissue has a key role in providing the optimum microenvironment for sustained malignant dissemination. Such a tissue may be a fixed or a mobile intravascular microsatellite, or an intravascular micrometastasis, which locally develops into an overt in-transit metastasis.

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Citations

Dec 18, 2001·The Journal of Pathology·D J RuiterUNKNOWN Pathology Committee of the EORTC Melanoma Group
Dec 11, 2007·Cancer Metastasis Reviews·François-Clément BidardMarie-France Poupon
Mar 24, 2012·Nature Protocols·Annique M M J DuyvermanRakesh K Jain
Mar 24, 2012·Nature Protocols·Annique M M J DuyvermanDan G Duda
Mar 24, 2012·Nature Protocols·Annique M M J DuyvermanDai Fukumura
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dan G DudaRakesh K Jain
Nov 27, 2010·BMC Research Notes·Jian LiCarsten Wiuf
Mar 22, 2002·The Lancet Oncology·Dirk RuiterMeenhard Herlyn
Apr 15, 2014·Neoplasia : an International Journal for Oncology Research·Gursah Kats-UgurluWilliam Leenders
Jun 15, 2007·Microvascular Research·Dai Fukumura, Rakesh K Jain
Oct 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dai Fukumura, Rakesh K Jain
Jul 27, 2012·International Journal of Cancer. Journal International Du Cancer·Michael Herman Chui
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dai FukumuraRakesh K Jain
Apr 13, 2005·Otolaryngologic Clinics of North America·Randall TaggArlen D Meyers
Apr 25, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F A VlemsG N P van Muijen
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
May 13, 2005·Physiology·David H GehoLance A Liotta
Jul 23, 2014·Clinical and Translational Medicine·Konrad SteinestelJulie Steinestel
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dirk J Ruiter, Meenhard Herlyn

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