Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours

Histopathology
Harri SihtoHeikki Joensuu

Abstract

To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells. KIT and SCF expression were studied in 248 human tumours consisting of 15 different histological types using immunohistochemistry and in situ hybridization for KIT messenger RNA. Moderate to strong intratumoral endothelial cell KIT expression was present in 11 of the 15 tumour types, and was most common in glioblastoma (58%), mixed embryonal carcinoma with teratoma (33%) and renal clear cell carcinoma (29%). Results of in situ hybridization were in line with those obtained with immunohistochemistry in the cases studied (n = 9). Marked SCF expression was uncommon in tumour endothelial cells, but frequent in perinecrotic tumour cells. Patients with glioblastoma with moderate to strong endothelial cell KIT expression had more favourable survival than those whose tumour showed little or no expression (P = 0.024). Glioblastoma patients whose tumour expressed SCF had an unfavourable outcome compared with those with tumour with weak or no expression (P = 0.034). Intratumoral microvessels of several types of human malignant tumours express KIT. Tumour cell SCF expression and absence of marked endothelial cel...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jun 11, 1999·The American Journal of Pathology·Q TianC A Moskaluk
May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MiettinenJ Lasota
Nov 28, 2001·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M ParikkaT Salo
May 5, 2004·The Journal of Clinical Investigation·Lixin SunHoward A Fine
Nov 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harri SihtoHeikki Joensuu
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Robert J MotzerM Dror Michaelson
Dec 26, 2006·Molecular Cancer Research : MCR·Marjut PuputtiNina N Nupponen
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Feb 13, 2007·The Journal of Pathology·H SihtoH Joensuu

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Citations

Feb 6, 2014·British Journal of Cancer·S LauttiaH Joensuu
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Marika WaltariHeikki Joensuu
Oct 14, 2010·Molecular Membrane Biology·Sylvia A KuijpersRaymond M Schiffelers
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·François KuonenCurzio Rüegg
Jun 26, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·François KuonenCurzio Rüegg

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