Tumour mutation status and melanoma recurrence following a negative sentinel lymph node biopsy

British Journal of Cancer
Nikki R AdlerVictoria J Mar

Abstract

A proportion of patients develop recurrence following a tumour-negative sentinel lymph node biopsy (SLNB). This study aimed to explore whether melanoma patients with BRAF or NRAS mutant tumours have an increased risk of developing disease recurrence following a negative SLNB compared to patients with wild-type tumours. Prospective cohort study of melanoma patients at three tertiary referral centres in Melbourne, who underwent SLNB. Clinical, pathological and molecular characteristics and recurrence data were prospectively recorded. Multivariate Cox proportional hazards regression models estimated the adjusted hazard ratio (aHR) and corresponding 95% confidence interval (CI) for the association between mutation status and development of recurrence following a negative-SLNB. Overall, 344/477 (72.1%) patients had a negative SLNB. Of these, 54 (15.7%) developed subsequent recurrence. The risk of disease recurrence following a negative SLNB was increased for patients with either a BRAF or NRAS mutant tumour compared to wild-type tumours (aHR 1.92, 95% CI: 1.02-3.60, p = 0.04). Melanoma patients with BRAF or NRAS mutant tumours had an increased risk compared to patients with BRAF/NRAS wild-type tumours of developing disease recurrenc...Continue Reading

References

Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Keiran S M Smalley
May 12, 2005·Annals of Surgical Oncology·Vivian S K YeeRoger F Uren
Sep 21, 2005·Archives of Surgery·Theresa G ZogakisDonald L Morton
Dec 13, 2006·The Journal of Investigative Dermatology·Wendy LiuGrant A McArthur
Mar 12, 2009·Annals of Surgical Oncology·W Charles ConwayDonald L Morton
Dec 8, 2009·Annals of Surgical Oncology·Charles R ScogginsKelly M McMasters
Oct 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie A EllerhorstElizabeth A Grimm
Nov 11, 2010·International Journal of Cancer. Journal International Du Cancer·Lutz KretschmerRalf Gutzmer
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georgina V LongRichard F Kefford
May 5, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nicole de RosaWalter T Lee
May 28, 2011·Pigment Cell & Melanoma Research·Bianca DevittGrant McArthur
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria ColombinoGiuseppe Palmieri
Jul 10, 2012·Annals of Surgical Oncology·Stéphanie MoreauJean-François Emile
Jul 24, 2012·Cell·Eran HodisLynda Chin
Jan 7, 2014·Journal of the American Academy of Dermatology·Eduardo NagoreElke Hacker
Feb 14, 2014·The New England Journal of Medicine·Donald L MortonUNKNOWN MSLT Group
Jul 30, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrew P BarbourNicholas K Hayward
Mar 11, 2015·The British Journal of Dermatology·V J MarJ W Kelly
Mar 31, 2015·Journal of the American Academy of Dermatology·Soo Young KimKyu Joong Ahn
Aug 20, 2015·Proceedings of the National Academy of Sciences of the United States of America·J Zachary SanbornRaymond J Cho
Oct 16, 2015·Melanoma Research·Emer P O'ConnellHenry P Redmond
Jun 8, 2017·The New England Journal of Medicine·Mark B FariesRobert M Elashoff
Jun 27, 2017·Journal of Surgical Oncology·Andrew J SinnamonGiorgos C Karakousis
Jul 15, 2017·The Australasian Journal of Dermatology·Omgo E NiewegJohn F Thompson
Jul 25, 2017·The Journal of Investigative Dermatology·Maximilian GassenmaierClaus Garbe
Sep 12, 2017·The New England Journal of Medicine·Georgina V LongJohn M Kirkwood
Sep 12, 2017·The New England Journal of Medicine·Jeffrey WeberUNKNOWN CheckMate 238 Collaborators

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Citations

Sep 12, 2019·JAMA Dermatology·Nikki R AdlerVictoria J Mar
Oct 23, 2020·European Journal of Cancer Care·Leire Loidi-PascualJuan Ignacio Yanguas-Bayona
May 7, 2021·ANZ Journal of Surgery·Daniel Wen, Richard C W Martin

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