Tumour necrosis factor a -308 promoter polymorphism in patients with rheumatoid arthritis

Rheumatology International
Zahra RezaieyazdiFarnaz Mohajer


There are controversial reports that TNF-a promoter polymorphism may be an independent marker of susceptibility to rheumatoid arthritis (RA). We used Polymerase chain reaction amplification and Restriction fragment length polymorphism for analysis of the polymorphism at position -308 in promoter of TNF-alpha gene in 34 patients with RA and 30 healthy individuals. Distribution of TNF-genotypes in RA patients did not differ from that in controls. Moreover, there was apparent association between the -308 TNF-alpha polymorphism and erosions in hand x-Ray was found (P value = 0.043). We suggest that TNF-alpha -308 promoter polymorphism is not a genetic risk factor for RA susceptibility but may be associated with radiographic damage in rheumatoid patients.


Jul 28, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hannan Al-RayesMohammad Tariq
Dec 7, 2013·Rheumatology International·Gwan Gyu SongYoung Ho Lee
Jan 8, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Thayse Rodrigues de SouzaLuiz Alcino Gueiros
Sep 22, 2016·SpringerPlus·Radwa R El-TahanNoha El-Mashad
Feb 7, 2018·Molecular Biology Reports·Daniel Cadena-SandovalJulián Ramírez-Bello
Oct 1, 2019·Molecular Genetics & Genomic Medicine·José de Jesús López-JiménezAna-Rebeca Jaloma-Cruz


Jul 1, 1995·Annals of the Rheumatic Diseases·A G WilsonG W Duff
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Jan 1, 1997·Tissue Antigens·J VinascoJ Martín
Feb 20, 2004·Genes and Immunity·J-P BayleyC L Verweij
Jun 21, 2005·Transplantation Proceedings·A PawlikB Gawronska-Szklarz
Aug 13, 2005·Scandinavian Journal of Rheumatology·A PawlikM Herczynska

Related Concepts

Tumor Necrosis Factor-alpha
Restriction Fragment Length Polymorphism
Nucleic Acid Amplification Tests
Polymerase Chain Reaction Analysis
Severity of Illness Index
Gene Amplification Technique
Erosion Lesion

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.