Tumour necrosis factor a -308 promoter polymorphism in patients with rheumatoid arthritis

Rheumatology International
Zahra RezaieyazdiFarnaz Mohajer

Abstract

There are controversial reports that TNF-a promoter polymorphism may be an independent marker of susceptibility to rheumatoid arthritis (RA). We used Polymerase chain reaction amplification and Restriction fragment length polymorphism for analysis of the polymorphism at position -308 in promoter of TNF-alpha gene in 34 patients with RA and 30 healthy individuals. Distribution of TNF-genotypes in RA patients did not differ from that in controls. Moreover, there was apparent association between the -308 TNF-alpha polymorphism and erosions in hand x-Ray was found (P value = 0.043). We suggest that TNF-alpha -308 promoter polymorphism is not a genetic risk factor for RA susceptibility but may be associated with radiographic damage in rheumatoid patients.

References

Jul 28, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hannan Al-RayesMohammad Tariq
Dec 7, 2013·Rheumatology International·Gwan Gyu SongYoung Ho Lee
Jan 8, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Thayse Rodrigues de SouzaLuiz Alcino Gueiros
Sep 22, 2016·SpringerPlus·Radwa R El-TahanNoha El-Mashad
Feb 7, 2018·Molecular Biology Reports·Daniel Cadena-SandovalJulián Ramírez-Bello
Oct 1, 2019·Molecular Genetics & Genomic Medicine·José de Jesús López-JiménezAna-Rebeca Jaloma-Cruz

Citations

Jul 1, 1995·Annals of the Rheumatic Diseases·A G WilsonG W Duff
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Jan 1, 1997·Tissue Antigens·J VinascoJ Martín
Feb 20, 2004·Genes and Immunity·J-P BayleyC L Verweij
Jun 21, 2005·Transplantation Proceedings·A PawlikB Gawronska-Szklarz
Aug 13, 2005·Scandinavian Journal of Rheumatology·A PawlikM Herczynska

Related Concepts

Hand
Necrosis
Tumor Necrosis Factor-alpha
Restriction Fragment Length Polymorphism
Nucleic Acid Amplification Tests
Polymerase Chain Reaction Analysis
Severity of Illness Index
Promoter
Gene Amplification Technique
Erosion Lesion

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