Tumour necrosis factor alpha suppression by MDMA is mediated by peripheral heteromeric nicotinic receptors

Immunopharmacology and Immunotoxicology
Jorge CamarasaElena Escubedo

Abstract

MDMA is an illegal drug widely used by young people. The present study aimed to determine the involvement of different nicotinic acetylcholine receptor (nAChR) subtypes in the suppressive effect of MDMA in TNF-alpha production. Dihydrobetaerythroidine (antagonist of heteromeric nAChR), and hexamethonium (antagonist of peripheral nAChR), fully antagonized the effect of MDMA. Conversely, methyllycaconitine (antagonist of homomeric nAChR), did not modify it. From in vitro experiments, a direct effect was ruled out. In this study we provide the first evidence that in rodents MDMA impairs the production of TNF-alpha by activation of heteromeric nAChR expressing beta-2 subunits located in the periphery.

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Citations

Aug 13, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·V Ferraz-de-PaulaJ Palermo-Neto
Dec 14, 2011·The Veterinary Quarterly·Irene Antolino-LoboMajorie B M van Duursen
Aug 20, 2010·British Journal of Pharmacology·Noreen T Boyle, Thomas J Connor
Mar 8, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrés Ciudad-RobertsElena Escubedo
May 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara L F KaplanPeer W F Karmaus
Nov 30, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea Magrone, Emilio Jirillo
Jun 21, 2019·Journal of Psychopharmacology·Sonia AbadElena Escubedo

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