Tumour Necrosis Factor-alpha (TNF-α) and its soluble receptor type 1 (sTNFR I) in human active and healed leishmaniases

Parasite Immunology
Mahmoud Nateghi RostamiAkram Miramin Mohammadi

Abstract

The role of tumour necrosis factor-alpha (TNF-α) is not fully understood in human leishmaniasis. We analysed the alterations in the levels of TNF-α, soluble TNF receptor type 1 (sTNFR I), IL-17 and IL-22 productions in active and healed leishmaniases. Blood samples were collected from volunteers with active cutaneous leishmaniasis (ACL), the same subjects after lesion healing (healed CL = HCL), volunteers with active visceral leishmaniasis (AVL), healed VL (HVL) and healthy controls. Levels of cytokines were titrated on Leishmania Ag-stimulated PBMC culture. The mean level of TNF-α production from stimulated cells was significantly higher in ACL than controls (P < 0·001) and significantly reduced after treatment in HCL volunteers (P < 0·05). The mean level of sTNFR I production was significantly higher in ACL than controls (P < 0·001) and significantly reduced after treatment in HCL volunteers (P < 0·05). The mean level of IL-22 production in AVL was significantly higher than controls (P < 0·05) and was significantly lower in HVL compared with AVL (P < 0·001) and controls (P < 0·05). The levels of TNF-α (P = 0·0025) and sTNFR I (P < 0·01) productions from PBMCs showed significant decreasing trend after treatment in each CL volu...Continue Reading

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Citations

Aug 19, 2016·Frontiers in Immunology·Sarah de Athayde Couto FalcãoCecília B F Favali
Feb 9, 2017·Scandinavian Journal of Immunology·M MoafiN Ansari
Aug 17, 2019·PLoS Neglected Tropical Diseases·Michaela FakiolaJenefer M Blackwell
Aug 16, 2018·Frontiers in Immunology·Katharina ArensGer van Zandbergen
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Nov 1, 2020·Cytokine·Renuka BhorKalpana Pai
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May 3, 2021·Medical Microbiology and Immunology·Mahmoud Nateghi Rostami, Ali Khamesipour
Apr 30, 2021·Parasite Immunology·Fatemeh DarziMahmoud Nateghi Rostami

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