PMID: 15230290Jul 3, 2004Paper

Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention

Lupus
Martin Aringer, Josef S Smolen

Abstract

Systemic lupus erythematosus (SLE) is an autoantibody and immune complex mediated disease. However, it is the ensuing inflammatory process that leads to irreversible organ damage. In fact several murine models of SLE suggest that this inflammatory organ damage can be prevented even in the presence of autoantibodies. Given data from experimental models as well as from patients, proinflammatory cytokines including tumour necrosis factor (TNF) alpha apparently play a significant role in the inflammatory process, but may have immunoregulatory functions at the same time. Therefore, anti-TNF alpha therapy may constitute an interesting candidate approach for treating SLE inflammatory organ disease, but potentially at the cost of increased autoantibody formation. Clinical trials will be required to answer whether TNF alpha blockade fulfils this hope with an acceptable safety profile. Interferon (IFN)-gamma, interleukin (IL)-18, IL-6 and possibly IL-1 are increased in SLE and likewise involved in the inflammatory process. Specific therapeutic agents for blocking these cytokines should be available in the near future.

References

Feb 1, 1992·Annals of the Rheumatic Diseases·J L ViannaG R Hughes
Sep 1, 1991·Clinical and Experimental Immunology·Y Deguchi, S Kishimoto
Sep 1, 1989·Clinical Immunology and Immunopathology·C GordonD Wofsy
Feb 1, 1989·Arthritis and Rheumatism·C P Maury, A M Teppo
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·T TakemuraS Maki
Aug 1, 1994·The Journal of Clinical Investigation·B K FinckD Wofsy
Dec 12, 1997·European Journal of Immunology·L FaggioliM Palmieri
Feb 7, 1998·The Journal of Clinical Investigation·D BalomenosA N Theofilopoulos
May 8, 1998·The New England Journal of Medicine·B H Hahn
Jun 2, 1998·Lupus·R Herrera-EsparzaE Avalos-Díaz
Dec 24, 1998·Lupus·C A von MühlenM J Fritzler
Dec 1, 1999·Annals of the Rheumatic Diseases·A N Theofilopoulos, B R Lawson
Sep 16, 2000·Current Opinion in Rheumatology·D S Pisetsky
Aug 21, 2001·Rheumatology·M AringerW B Graninger
Sep 21, 2002·Lancet·Aparna K MohanM Miles Braun
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paola BossùDiana Boraschi

❮ Previous
Next ❯

Citations

Jul 5, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V Z C BorbaM Lazaretti-Castro
Feb 28, 2006·Zeitschrift für Rheumatologie·M Aringer, J Smolen
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Xavier Valencia, Peter E Lipsky
Nov 23, 2005·The Journal of Experimental Medicine·Yasutaka OkabeShigekazu Nagata
Apr 19, 2008·DNA and Cell Biology·Ma-feng LiuMing-yuan Liu
Sep 10, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Divaker ChoubeyHongzhu Liu
Dec 14, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Divaker Choubey, Kamal D Moudgil
Apr 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael B StokesVivette D D'Agati
Jun 6, 2008·Journal of Clinical Neuromuscular Disease·Juan J FigueroaDavid N Herrmann
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Lang-Jing ZhuXue-Qing Yu
Apr 9, 2008·American Journal of Respiratory Cell and Molecular Biology·María Elena MonzónRosanna M Forteza
Apr 4, 2007·The Journal of Clinical Investigation·Jingwu Zhang
Oct 18, 2013·QJM : Monthly Journal of the Association of Physicians·T BurkardUNKNOWN Time-CHF Investigators
Feb 5, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Agnieszka Nielepkowicz-GoździńskaAdam Antczak
Nov 5, 2013·Clinical & Developmental Immunology·Dorothy MangaleTimothy B Niewold
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Ellen M Ginzler, Olga Dvorkina
Jun 7, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sumapa ChaiamnuayUNKNOWN LUMINA Study Group
Jul 1, 2008·Der Internist·M Pierer, C Baerwald
Jan 1, 2007·Expert Review of Clinical Immunology·Jingwu Zhang
Nov 24, 2007·Expert Review of Vaccines·Detlef NeumannDiana Boraschi
Mar 1, 2009·Expert Opinion on Medical Diagnostics·Irene Meester, Juan Manuel Solis-Soto
Jan 17, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Divaker Choubey
Jan 3, 2012·Biochemical Pharmacology·Matthew M Seavey, Pawel Dobrzanski
Nov 22, 2011·Journal of Inorganic Biochemistry·Lucija Tomljenovic, Christopher A Shaw
Oct 30, 2010·La Revue de médecine interne·L Arnaud, Z Amoura
Mar 6, 2007·Seminars in Nephrology·Volker VielhauerDetlef Schlöndorff
Jul 16, 2008·La Revue de médecine interne·Z AmouraJ-C Piette
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Mary Anne Dooley, Ellen M Ginzler
Apr 6, 2005·Clinical and Experimental Immunology·F Goldblatt, D A Isenberg
May 1, 2007·Arthritis and Rheumatism·Peter E WesterweelMarianne C Verhaar
Mar 17, 2009·Journal of Clinical Laboratory Analysis·Shih-Yin ChenFuu-Jen Tsai
Nov 28, 2008·Arthritis and Rheumatism·Shilpa GaitondeIrving Kushner
Jan 11, 2007·Scandinavian Journal of Immunology·G L BjornssonB Gudbjornsson
Aug 21, 2010·Journal of Food Science·Yu-Ting KuoChih-Hsing Hung
May 9, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Rubén ArmañanzasAna M Zubiaga
Oct 3, 2014·Clinical Reviews in Allergy & Immunology·Britt NakkenPeter Szodoray
Dec 28, 2006·Journal of the American Academy of Dermatology·Julia E GravesMichael P Heffernan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.