PMID: 2106723Feb 1, 1990Paper

Tumour necrosis factor in hepatosplenic schistosomiasis

Scandinavian Journal of Immunology
K ZwingenbergerH Feldmeier

Abstract

Periportal fibroplasia is the dominating feature of hepatosplenic schistosomiasis. Since monokines play an important role in the regulation of fibroplasia, tumour necrosis factor (TNF) and interleukin 1 beta (IL-1 beta) were assessed in sera and cell culture supernatants from patients with intestinal and hepatosplenic schistosomiasis before and 3-6 months after treatment with praziquantel. Uninfected controls were from the study area in Alagoas, Brazil. TNF was measured using an L-M mouse fibroblast bioassay and radioimmunoassays specific for TNF-alpha. Whereas TNF-alpha was elevated threefold in the patients' sera, three- to five-fold reductions of TNF were observed by radioimmunoassay and bioassay, respectively, in cell culture supernatants of hepatosplenic schistosomiasis patients. Significant deviations, in opposite directions, from TNF levels in control sera and supernatants are most plausible in the event of a sequestration of TNF-alpha-producing cells from the circulation. This process may be disease stage-specific since a dichotomy between incipient and advanced cases of hepatosplenic schistosomiasis became apparent in the amplitude and kinetics of changes during the follow-up after treatment.

References

Nov 6, 1986·Journal of Immunological Methods·S M Kramer, M E Carver
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Jan 1, 1955·The American Journal of Tropical Medicine and Hygiene·W BLAGGG I KHALAF

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Citations

Jan 1, 1996·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Y He, W Liu
Feb 27, 2007·Parasitology Research·Roba M TalaatMaged M Al-Sherbiny
Sep 19, 2003·International Journal for Parasitology·Rupert J Quinnell
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Jun 26, 2008·Acta Tropica·Iramaya Rodrigues CaldasGiovanni Gazzinelli
Oct 26, 2005·Molecular and Biochemical Parasitology·Munirathinam GnanasekarKalyanasundaram Ramaswamy
Mar 6, 2007·Trends in Parasitology·Jennifer F FriedmanJonathan D Kurtis
Sep 14, 2004·Immunological Reviews·Miguel J StadeckerJing Sun
Jun 1, 1990·Scandinavian Journal of Immunology·K ZwingenbergerA R Correia Dacal
Jun 2, 2005·European Journal of Clinical Nutrition·J F FriedmanF ter Kuile
Sep 6, 2005·Parasite Immunology·W E Secor
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jasim UddinJon S Friedland
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Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark BoothDavid W Dunne
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick M SmithMiguel J Stadecker
Sep 1, 1994·International Journal of STD & AIDS·H FeldmeierG Poggensee
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker

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